New · posted Nov 3
Tango Therapeutics · Biotechnology
Clinical Trials Manager
- Boston, MA
- Hybrid
- Full-time
- Manager
The role
We are seeking a Clinical Trial Manager (CTM) to lead operational aspects of a clinical trial and support the Clinical Trial Leader (CTL), as required. This role will serve as a key member of the Clinical Trial Team (CTT) and as the primary contact for external parties and vendors. CTM may lead the cross-functional CTT for smaller and less complex trials or manage critical aspects of larger and more complex clinical trials under CTL leadership. In addition, CTM will be responsible for site management oversight for trials where no Site Management Leader (SML) is assigned.
In a fast-paced, small biotech environment, the CTM will operationally manage the set-up, conduct and reporting of clinical trials (or parts thereof) as per approved timelines, budget, regulatory requirements, and internal standards. This individual will play a key role in the execution and delivery of clinical trial objectives.
The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.
What you need
What You Bring
- 5+ years of trial management experience. Leadership experience (preferred)
- Bachelor’s degree in Life Sciences, Pharmacy or related field
- Experience working in global clinical development organization
- Experience in Oncology development (preferred)
- Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred)
- Experience in outsourcing and oversight
- Knowledge of ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines
- Knowledge of financial planning, tracking, and reporting
- Knowledge of trial risk assessment and management
- Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and site management metrics, KPIs, and KRIs
- Strong vendor management and project management skills
- Leadership skills with the ability to lead cross-functional teams
- Strong interpersonal and communication skills
- Strong analytical thinking and decision-making capabilities
- Willingness to travel, as required (typically 10–20%)
What you'll do
Your Role
- Serve as a core member of the Clinical Trial Team (CTT) and act as deputy for the Clinical Trial Leader (CTL) during absences
- Organize and coordinate CTT meetings, including preparing agendas, recording minutes, and tracking follow-up actions
- Facilitate communication and collaboration within the team and with external partners such as Contract Research Organizations (CROs) and vendors
- Contribute to the development and maintenance of trial-level documents and operational plans, including project management, communication, risk management, and quality plans
- Establish and manage trial-related systems and processes (e.g., central laboratories, eCOA/ ePRO) in alignment with protocol requirements
- Monitor CRO/ vendor performance and ensure timely and accurate data integration, transfer, and reconciliation. Escalate issues to the CTL, as needed
- Identify risks and issues and support the development and implementation of mitigation strategies and action plans
- Maintain accurate and up-to-date trial information in systems and communication tools
- Set up and maintain clinical trial insurance in participating countries
- Coordinate with the global supply chain to ensure timely supply and distribution of devices and investigational medicinal products, comparator or co-medication to clinical sites
- Prepare and distribute trial-related correspondence and contribute to the development of materials for meetings, newsletters, and websites
- Lead logistical arrangements and support content development for external meetings such as investigator meetings and advisory boards
- Ensure ongoing inspection and audit readiness. Participate in internal audits and regulatory inspections, as required
- Support budget forecasting and accrual processes. Assist with invoice tracking, and processing in line with vendor contracts
- Act as CTL when assigned, leading cross-functional CTT to operationalize the protocol of a clinical trial
- Lead the development of site management oversight plan and ensure site management oversight including risk management for trials without assigned Site Management Lead (SML)
Pay
$120,000 – $180,000 a year
Employer provided$120,000—$180,000 USD
Where you'll work
Boston, MAHybridOpen in Maps (opens in a new tab)
More jobs in Boston, MA
From the posting
About Tango Therapeutics
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts
Equal opportunity, accessibility and legal noticesTango Therapeutics's statements, word for word
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Job intelligence
The context around this role
Live data · November 3, 2026
Salary intelligence
How the pay compares
This role's midpoint is 8% below the US median for Clinical Trial Management roles at this level.
This roleEmployer provided
Manager roles in Massachusetts10 roles publishing pay
Manager roles in the US45 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $120,000 | — | $180,000 |
| Massachusetts (middle half) | $142,250 | $169,750 | $176,500 |
| All US (middle half) | $149,000 | $163,000 | $175,000 |
This role: Tango Therapeutics's own published range. Comparisons: the base pay employers published on open Clinical Trial Management roles at the same level on Regulatory Jobs, November 3, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Trial Management
The general path across 70 open Clinical Trial Management roles on Regulatory Jobs, with the titles they carry most. Not Tango Therapeutics's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 34 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Collaboration and leadership14
- Clinical trial conduct13
- GMP and compliance3
- Quality systems and risk3
- Lab testing and methods2
- Investigations and CAPA2
- Documentation and SOPs1
- Regulatory submissions1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
Company hiring pulse
Tango Therapeutics on Regulatory Jobs
- 8
- Open roles
- 8
- Distinct roles
- 1
- Locations
By discipline
- Clinical5 63%
- Quality3 38%
By level
- Director4 50%
- Manager3 38%
- Senior & Principal1 13%
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Clinical Trials Manager at Tango Therapeutics
Open until filled. $120K–$180K a year, employer provided.