New · posted Oct 31
Tango Therapeutics · Biotechnology
Senior Director, Clinical Development
- Boston, MA
- Hybrid
- Full-time
- Director
The role
The Senior Director, Clinical Development will provide medical and scientific leadership for Tango’s oncology development programs, driving clinical strategy from early-stage development through registration. Reporting to the President, Research & Development, this individual will lead cross-functional clinical teams, shape development plans, oversee study execution and medical monitoring, and serve as a key partner to investigators, regulators, and senior leadership.
This highly visible role combines strategic leadership with hands-on clinical development responsibilities and offers the opportunity to directly influence the advancement of innovative precision oncology therapies for patients. The Senior Director will build and maintain strong relationships with investigators, key opinion leaders (KOLs), and external partners while ensuring the successful execution of clinical studies and overall program objectives.
What you need
What You Bring
- MD required; board certification or board eligibility in Medical Oncology, Hematology/Oncology, or a related specialty strongly preferred
- 5+ years of clinical development experience within the biotechnology and/or pharmaceutical industry, including experience leading oncology development programs
- Demonstrated experience in the design, execution, interpretation, and reporting of oncology clinical trials involving targeted therapies, small molecules, and/or immuno-oncology agents
- Experience supporting or leading late-stage clinical development programs, NDA/BLA/MAA submissions, and Health Authority interactions
- Strong understanding of the biological and translational sciences underlying modern oncology drug development, including molecular biology, cancer genetics, immunology, and precision medicine approaches
- Proven ability to lead and influence cross-functional teams within a matrixed organization
- Excellent strategic thinking, organizational, and project leadership skills, with the ability to balance high-level planning and hands-on execution
- Strong problem-solving skills and the ability to identify innovative approaches to advance development programs and organizational objectives
- Exceptional communication and presentation skills, including the ability to engage effectively with senior leadership, investigators, KOLs, and regulatory agencies
- Demonstrated leadership capabilities with a collaborative, team-oriented, and results-driven approach
- Flexible, resourceful, and entrepreneurial mindset with the ability to thrive in a dynamic and fast-paced biotechnology environment
Skills named in this posting
What you'll do
Your Role
- Lead the clinical development strategy and execution for assigned clinical-stage oncology asset(s), partnering with cross-functional teams to create and implement comprehensive clinical development plans
- Provide leadership to the clinical team and serve as the medical and scientific expert for development programs
- Design, author, and oversee the development of study protocols, protocol amendments, investigator brochures, and other key clinical documents in compliance with project plans, global regulations, ICH/GCP guidelines, and Good Medical Practice
- Serve as the primary clinical lead for study investigators and key opinion leaders, building strong relationships that support program success and scientific advancement
- Lead clinical contributions to regulatory submissions, including INDs, CTAs, NDA/MAA filings, and interactions with Health Authorities
- Act as Medical Monitor and/or oversee external Medical Monitors for company-sponsored clinical trials, ensuring appropriate medical oversight and patient safety
- Provide strategic oversight of adverse event review, safety monitoring, protocol compliance, and clinical data evaluation
- Partner closely with Clinical Operations, Clinical Pharmacology, Biometrics, Regulatory Affairs, Drug Safety, Data Management, Quality, and Translational Sciences to ensure integrated and efficient execution of development programs
- Analyze and interpret clinical trial data and communicate findings through regulatory submissions, scientific publications, medical congress presentations, and internal governance reviews
- Lead responses to questions from Health Authorities, Ethics Committees, and Institutional Review Boards, ensuring consistency and scientific rigor
- Contribute to portfolio strategy, development planning, and broader organizational initiatives as needed
- Perform additional responsibilities as required to support the advancement of Tango’s clinical programs
Pay
$274,400 – $411,600 a year
Employer provided$274,400—$411,600 USD
Where you'll work
Boston, MAHybridOpen in Maps (opens in a new tab)
More jobs in Boston, MA
From the posting
About Tango Therapeutics
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Equal opportunity, accessibility and legal noticesTango Therapeutics's statements, word for word
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 15% above the US median for Clinical Development roles at this level.
This roleEmployer provided
Director roles in Massachusetts40 roles publishing pay
Director roles in the US93 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $274,400 | — | $411,600 |
| Massachusetts (middle half) | $255,000 | $298,000 | $308,250 |
| All US (middle half) | $258,000 | $298,000 | $318,500 |
This role: Tango Therapeutics's own published range. Comparisons: the base pay employers published on open Clinical Development roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Development
The general path across 116 open Clinical Development roles on Regulatory Jobs, with the titles they carry most. Not Tango Therapeutics's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 25 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Clinical trial conduct12
- Collaboration and leadership12
- Investigations and CAPA5
- Regulatory submissions4
- GMP and compliance2
- Documentation and SOPs1
- Data and digital systems1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
- ICHICH quality guidelines(official source, opens in a new tab)Q1 stability, Q2(R2) analytical validation, Q7, Q9 risk management, Q10 quality systems
- ICHICH E6 good clinical practice(official source, opens in a new tab)The international standard for the conduct of clinical trials
- FDAFDA IND(official source, opens in a new tab)Investigational New Drug applications
- FDAFDA NDA(official source, opens in a new tab)New Drug Applications
- FDAFDA BLA(official source, opens in a new tab)Biologics License Applications
Company hiring pulse
Tango Therapeutics on Regulatory Jobs
- 7
- Open roles
- 7
- Distinct roles
- 1
- Locations
By discipline
- Clinical4 57%
- Quality3 43%
By level
- Director4 57%
- Manager2 29%
- Senior & Principal1 14%
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Senior Director, Clinical Development at Tango Therapeutics
Open until filled. $274K–$412K a year, employer provided.