New · posted Oct 31
Vertex Pharmaceuticals · Biotechnology
Senior Medical Director, Clinical Development- Nephrology
- Boston, MA
- Hybrid
- Full-time
- Director
The role
The Senior Medical Director will define the clinical development strategy of povetacicept in primary membranous nephropathy, work with cross-functional multidisciplinary teams to define overall asset strategy as well as clinical trials strategy, design and execution, and may serve as the Medical Lead for clinical trials that will be conducted with these compounds.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]
What you need
- MD, DO or equivalent ex-US medical degree
- Board certification/eligibility in a specialty is highly desired
- Typically requires 12 years Pharmaceutical/Biotech industry experience, including time managing clinical trials and clinical development programs, or the equivalent combination of education and experience
- Supervisory experience required
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Knowledge and Skills
- Global clinical research experience, and experience interacting with regulatory authorities is highly desired
- Ability to work collaboratively in a fast-paced, team-based matrix environment
- Ability to work independently to resolve challenges
- Enterprise-wide thinking and ability to work in ambiguity
- Ability to ensure the completeness of team work
- Excellent oral and written communication skills
- Board certification/eligibility in a specialty is highly desired.
What you'll do
- Defines a clinical development strategy and prepare the clinical development plans, in conjunction with other relevant functional areas
- Participates in the development of study protocols, statistical analysis plans, investigator's brochures, and other key study documents in conjunction with other line functions and with minimal guidance
- Leads the Project Team, and works with cross-functional team members to define a project strategy and ensure execution against approved strategy
- Participates in the preparation of regulatory documents in support of regulatory submissions, including clinical section of INDs and CTAs, safety reports, responses to regulatory authorities, clinical study reports, and other documents as appropriate
- Interfaces with regulatory authorities as appropriate
- Monitors and/or oversees medical monitoring of clinical studies
- Participates in business development and strategic planning activities
- Acts as liaison between clinical development and other internal groups at Vertex for assigned studies
- Provides medical and development leadership for cross-functional teams
- Serves on cross-functional study teams for assigned trials, working with other team members to achieve efficient, high-quality study execution, and data analysis
- Represents Vertex to outside medical personal in the development of clinical protocols and study conduct
- As a people manager within the organization, may have financial accountabilities and human resource responsibilities for assigned staff.
Pay and benefits
$280,600 – $420,800 a year
Employer provided$280,600 - $420,800
Medical, dental and vision benefits
Generous paid time off
Company shutdown in Summer and Winter
Student loan repayment and educational assistance
Commuting subsidy
401(k)
Where you'll work
Boston, MAHybridOpen in Maps (opens in a new tab)
More jobs in Boston, MAWorking conditions
Flex Designation
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status
In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
From the posting
About Vertex
Vertex is a global biotechnology company that invests in scientific innovation.
Equal opportunity, accessibility and legal noticesVertex Pharmaceuticals's statements, word for word
Disclosure Statement
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 18% above the US median for Clinical Development roles at this level.
This roleEmployer provided
Director roles in Massachusetts40 roles publishing pay
Director roles in the US93 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $280,600 | — | $420,800 |
| Massachusetts (middle half) | $255,000 | $298,000 | $308,250 |
| All US (middle half) | $258,000 | $298,000 | $318,500 |
This role: Vertex Pharmaceuticals's own published range. Comparisons: the base pay employers published on open Clinical Development roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Development
The general path across 116 open Clinical Development roles on Regulatory Jobs, with the titles they carry most. Not Vertex's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 26 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Clinical trial conduct9
- Collaboration and leadership7
- Documentation and SOPs2
- Investigations and CAPA1
- Regulatory submissions1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
Company hiring pulse
Vertex on Regulatory Jobs
- 46
- Open roles
- 46
- Distinct roles
- 2
- Locations
By discipline
- Clinical20 43%
- Quality15 33%
- Regulatory11 24%
By level
- Director39 85%
- Manager5 11%
- VP & Executive1 2%
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Senior Medical Director, Clinical Development- Nephrology at Vertex
Open until filled. $281K–$421K a year, employer provided.