New · posted Oct 31
Iambic Therapeutics · Biotechnology
Senior Clinical Trial Manager, Clinical Operations
- Remote, US
- Remote
- Full-time
- Manager
The role
The Senior Clinical Trial Manager, Clinical Operations, serves as the operational lead for assigned early-phase oncology studies, providing end-to-end trial leadership from start-up through close-out. In close partnership with Clinical Development, Regulatory, Biometrics, and external CROs, this role drives high-quality, inspection-ready trial execution within a collaborative, growth-stage biotech environment. The Senior CTM is accountable for vendor oversight, risk management, timeline and budget performance, and cross-functional alignment to ensure studies are delivered efficiently and in compliance with global regulatory requirements, ICH-GCP, and company SOPs. This position reports to the Director of Clinical Operations and can be remote or onsite in San Diego.
What you need
Bachelor’s degree in life sciences or related field with 7+ years of progressive clinical trial management experience in biotech, pharmaceutical, and/or CRO environments
Demonstrated expertise managing clinical trials from start-up through close-out, with experience overseeing global, multi-site studies and CRO partners
Experience in oncology clinical trials required; solid tumor and early-phase (Phase I/Ib or II) experience preferred
In-depth knowledge of ICH-GCP, FDA/EMA regulations, and global regulatory requirements, with a strong focus on quality and inspection readiness
Proficiency with clinical trial systems, including CTMS, eTMF platforms, IRT systems, EDC systems, and safety databases
Ability to thrive in a collaborative, fast-paced, growth-stage biotech environment with evolving priorities and high accountability
What you'll do
Provide end-to-end operational leadership for complex clinical trials from start-up through close-out, ensuring delivery on time, within budget, and in compliance with global regulations and company SOPs
Lead cross-functional study teams and drive alignment across Clinical Development, Regulatory, Biometrics, and external partners
Develop and execute enrollment, site management, and monitoring strategies to ensure high-quality trial conduct and performance
Oversee CRO and vendor performance, including KPI management, monitoring quality oversight, document review and approval, and vendor selection support
Partner with Data Management and Medical to conduct ongoing data review and ensure timely query resolution
Develop and manage key study documents and operational tools, including protocols, informed consent forms, project plans, budgets, and study materials.
Lead study-related training for investigators, site personnel, and internal teams.
Proactively identify, assess, and escalate operational risks with mitigation strategies and clear recommendations.
Mentor and support junior clinical operations staff, including potential dotted-line management responsibilities.
Travel up to 10% as required to support study oversight and site engagement
Pay and benefits
$152,000 – $190,000 a year
Employer providedCompany-paid healthcare
Flexible spending accounts
Voluntary life insurance
401K matching
Uncapped vacation
Onsite gym and dining
From the posting
About Iambic
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 2% above the US median for Clinical Operations roles at this level.
This roleEmployer provided
Manager roles in the US6 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $152,000 | — | $190,000 |
| All US (middle half) | $164,250 | $167,500 | $170,750 |
This role: Iambic Therapeutics's own published range. Comparisons: the base pay employers published on open Clinical Operations roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Operations
The general path across 42 open Clinical Operations roles on Regulatory Jobs, with the titles they carry most. Not Iambic's own promotion track.
Career resources on Clinical Operations
Skills DNA
What this role leans on
How many of the posting's 17 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Clinical trial conduct11
- Collaboration and leadership6
- Documentation and SOPs5
- GMP and compliance3
- Data and digital systems2
- Investigations and CAPA1
- Quality systems and risk1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
Company hiring pulse
Iambic on Regulatory Jobs
- 7
- Open roles
- 7
- Distinct roles
- 2
- Locations
By discipline
- Clinical6 86%
- Regulatory1 14%
By level
- Director3 43%
- Manager2 29%
- Senior & Principal2 29%
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Senior Clinical Trial Manager, Clinical Operations at Iambic
Open until filled. $152K–$190K a year, employer provided.