New · posted Oct 31
Iambic Therapeutics · Biotechnology
Lead Clinical Data Manager
- Remote, US
- Remote
- Full-time
- Senior & Principal
The role
We are seeking a Lead Clinical Data Manager to serve as the primary Data Management resource on one or more clinical studies, directing activities from study start-up through database lock and close-out. This role provides project-level leadership across the full data management lifecycle, oversees CRO and EDC vendor performance, and represents Data Management on cross-functional study teams. The ideal candidate combines strong technical Data Management expertise with the ability to lead, mentor, and drive high-quality, on-time deliverables in a fast-paced environment.
What you need
Required
BA/BS degree in a scientific discipline, nursing, business, or information systems, with 7–10+ years of clinical data management experience, including sponsor and/or CRO-side experience
Advanced knowledge of EDC systems (Medidata Rave preferred) and clinical data structures
Demonstrated experience overseeing CRO and EDC vendor performance and deliverables
Strong knowledge of FDA regulations, ICH guidelines, Good Clinical Practice, and HIPAA
Oncology experience and knowledge of RECIST/RANO response criteria
Excellent communication, organizational, and cross-functional collaboration skills
Ability to travel approximately 10%, or as needed for business-critical activities
Preferred
Experience supporting health authority inspections or audits
Experience with Phase III pivotal studies
Working knowledge of SAS or other programming/reporting tools (e.g., Excel, Spotfire, Python) to generate listings, review outputs
What you'll do
Serve as the primary point of contact for Data Management activities on assigned studies, coordinating with sponsors, CROs, and cross-functional teams
Manage clinical data activities across the full study lifecycle, from database setup and design through database lock and archival, including Database UAT, query management, and data cleaning activities, with third-party data reconciliation (e.g., SAE, labs, IRT/RTSM, ePRO)
Author and maintain core Data Management study documentation, including the Data Management Plan (DMP), Data Review Plan (DRP), eCRF/CRF Completion Guidelines, Data Review Guidelines, Medical Coding Guidelines, and Data Transfer Agreements
Provide oversight of Data Management CRO and EDC vendor performance, ensuring deliverables meet SOPs, timelines, and quality expectations; assist with vendor selection activities, risk assessment, timeline and resource planning, and proactive issue escalation as needed
Represent Data Management on project teams, internal and external working groups, at investigator meetings, and during sponsor/health authority inspections and audits
Ensure consistent application of data standards and CDISC conventions (CDASH, SDTM) across assigned studies
Contribute to Data Management process improvement initiatives, Standard Operating Procedures (SOPs), and Work Instructions (WIs)
Ensure Data Management activities comply with SOPs, Work Instructions, ICH-GCP, and applicable regulations
Pay and benefits
$152,000 – $190,000 a year
Employer providedCompany-paid healthcare
Flexible spending accounts
Voluntary life insurance
401K matching
Uncapped vacation
From the posting
About Iambic
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 16% above the US median for Clinical Data Management roles at this level.
This roleEmployer provided
Senior & Principal roles in the US7 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $152,000 | — | $190,000 |
| All US (middle half) | $132,500 | $148,000 | $159,500 |
This role: Iambic Therapeutics's own published range. Comparisons: the base pay employers published on open Clinical Data Management roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Data Management
The general path across 29 open Clinical Data Management roles on Regulatory Jobs, with the titles they carry most. Not Iambic's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 21 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Data and digital systems10
- Clinical trial conduct8
- GMP and compliance4
- Documentation and SOPs4
- Collaboration and leadership4
- Regulatory submissions2
- Quality systems and risk2
- Investigations and CAPA1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
Company hiring pulse
Iambic on Regulatory Jobs
- 7
- Open roles
- 7
- Distinct roles
- 2
- Locations
By discipline
- Clinical6 86%
- Regulatory1 14%
By level
- Director3 43%
- Manager2 29%
- Senior & Principal2 29%
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Lead Clinical Data Manager at Iambic
Open until filled. $152K–$190K a year, employer provided.