New · posted Oct 31
UniQure Biopharma B.V. · Biotechnology
Medical Director, Clinical Trial Lead
- Remote, US
- Remote
- Full-time
- Director
The role
Place in the Organization
uniQure is dedicated to bring innovative therapies or unmet medical needs to patients. In doing so each function in uniQure is directly or indirectly responsible for the lives of patients. This responsibility should be part of our day-to-day working life by (i) living up to high quality standards and (ii) by recognizing the sense of urgency in areas of high medical need.
The Medical Director will lead and oversee clinical trials based in the US. The successful candidate will be responsible for leading clinical trials, engaging with Key Opinion Leaders (KOLs) and stakeholders, and ensuring the successful execution and monitoring of ongoing trial activities, including safety and efficacy assessments. This role requires a deep understanding of trial execution, with a strong background in clinical research and drug development, preferably in neurology or rare disease.
What you need
Stakeholder Engagement
- Develop and maintain strong relationships with Key Opinion Leaders (KOLs), clinical investigators, study coordinators, and other relevant stakeholders.
- Serve as a key point of contact for external partners, including clinical sites and contract research organizations (CROs) in terms of medical questions related to study readouts and assessments.
- Represent the company at scientific conferences, patient events and advisory boards.
Safety and Efficacy Monitoring
- Oversee the monitoring of trial activities, including patient safety, adverse event reporting, and efficacy assessments.
- Support the study team in the review and interpretation of clinical trial data, providing insights and recommendations for trial progression.
- Collaborate with the Medical Safety and PV team (internal and external) to ensure timely reporting and resolution of safety issues.
Regulatory and Compliance
- Ensure that all clinical trial activities comply with FDA regulations, Good Clinical Practice (GCP) guidelines, and other relevant regulatory requirements.
- Participate in the preparation of regulatory submissions, including clinical trial protocols amendments, and safety reports.
Team Collaboration
- Work closely with cross-functional teams, including clinical operations, regulatory and medical affairs, medical safety and writing, and biostatistics, to ensure the successful execution of clinical trials.
- Educate and provide guidance to uniQure clinical staff and research team in terms of epilepsy relevant aspects and related assessments.
Qualifications & Skills
- MD degree with board certification, preferably in neurology.
- Minimum of 5 years of clinical experience, with a focus in neurology or rare disease preferred.
- Proven experience in leading and conducting Phase I and II clinical trials.
- Ability to travel to study sites, attend required meetings, and conferences.
- Excellent communication and interpersonal skills, with the ability to engage effectively with KOLs, clinical investigators, and regulatory authorities.
- Ability to interpret and analyze clinical trial data, with a focus on safety and efficacy.
- Knowledge of FDA regulations and guidelines for clinical trial, GCP guidelines, and clinical trial processes.
- Experience in medical writing and regulatory submissions is a plus.
- Experience in gene therapy trials is a plus.
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant, relevant years of experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from where they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
US Salary Range
$205,000—$265,000 USD
uniQure posts all open positions exclusively on our official Careers page and LinkedIn. We do not recruit through any other job boards, third-party websites, or unsolicited outreach via text or messaging apps. All legitimate communication from uniQure’s Talent Acquisition team will come from an @uniqure.com email address. We will never request financial information nor payment of any kind during the application process. If you receive suspicious outreach claiming to be from uniQure, do not respond or share personal information. Inquiries can be made via [email protected].
Clinical Trial Leadership
- Lead and oversee clinical trials focused, ensuring adherence to regulatory and ethical standards.
- Collaborate with the clinical development team to support study design, implement, and monitor clinical trial protocols, with a focus on safety, efficacy, and regulatory compliance.
- Provide expert guidance on patient selection criteria, dosing regimens, and endpoints.
Pay
$205,000 – $265,000 a year
Employer providedEqual opportunity, accessibility and legal noticesUniQure Biopharma B.V.'s statements, word for word
uniQure is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, sexual orientation, or gender identity), national origin, age, disability, genetic information, marital status, veteran or military status, or any other characteristic protected by applicable federal, state, or local laws. If you need assistance or a reasonable accommodation during the application process, please contact [email protected].
uniQure processes personal data submitted through this application for recruitment and hiring purposes only. Depending on your location, you may have specific rights regarding your personal data. For full details on how we collect, use, store, and protect your information — including disclosures for California residents under the CCPA and for applicants under the GDPR — please review our applicant privacy notice.
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 21% below the US median for Clinical Development roles at this level.
This roleEmployer provided
Director roles in Massachusetts40 roles publishing pay
Director roles in the US93 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $205,000 | — | $265,000 |
| Massachusetts (middle half) | $255,000 | $298,000 | $308,250 |
| All US (middle half) | $258,000 | $298,000 | $318,500 |
This role: UniQure Biopharma B.V.'s own published range. Comparisons: the base pay employers published on open Clinical Development roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Development
The general path across 116 open Clinical Development roles on Regulatory Jobs, with the titles they carry most. Not uniQure's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 28 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Clinical trial conduct14
- Collaboration and leadership11
- GMP and compliance3
- Documentation and SOPs3
- Investigations and CAPA2
- Regulatory submissions2
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
Company hiring pulse
uniQure on Regulatory Jobs
- 5
- Open roles
- 5
- Distinct roles
- 2
- Locations
By discipline
- Regulatory2 40%
- Quality2 40%
- Clinical1 20%
By level
- Director3 60%
- VP & Executive2 40%
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Medical Director, Clinical Trial Lead at uniQure
Open until filled. $205K–$265K a year, employer provided.