

New · posted Nov 11
AstraZeneca · Pharmaceuticals
Senior Group Director, Clinical Scientist - Immunology
- Cambridge, MA
- On-site
- Full-time
- Director
The role
Are you an accomplished clinical scientist and people leader who can combine strategic clinical-development leadership with rigorous study execution? This role offers the opportunity to shape immunology programs, build clinical-science capability, and lead a high-performing team focused on delivering decision-ready evidence for patients with serious immune-mediated disease. We are seeking a Senior Group Director, Clinical Scientist, Immunology to drive clinical science across our immunology portfolio and lead a team of scientists.
The Senior Group Director, Clinical Scientist is a senior scientific and functional leader with accountability across people leadership, capability development, portfolio resourcing, program and study strategy, and clinical science delivery. The role line manages Clinical Scientists, contributes to departmental leadership, and will also serve as Clinical Scientist for programs and studies. Working in close partnership with Program and Study Physicians, Global Clinical Program Leads, Translational Medicine, Bioscience, Clinical Operations, Biostatistics, Data Management, Pharmacovigilance, Regulatory, and external partners, the role converts clinical-development strategy into high-quality, inspection-ready execution and clear recommendations for governance.
Date Posted
10-Nov-2026
Closing Date
29-Nov-2026
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
What you need
Essential Qualifications and Skills
· Advanced clinical or scientific degree, such as PhD, PharmD, MD, or an equivalent qualification in a relevant life-sciences discipline.
· Typically 10 or more years of relevant clinical-development experience, including substantial experience leading clinical programs or complex studies and delivering through global matrix teams.
· Demonstrated line-management experience, including talent selection, objective setting, performance and development conversations, resource allocation, and coaching of scientists at different career stages.
· Deep knowledge of end-to-end clinical and pharmaceutical drug development, clinical-trial methodology, benefit-risk evaluation, and global regulatory expectations.
· Proven authorship, leadership, or senior review of clinical development plans, protocols, amendments, Investigator’s Brochures, informed consent forms, safety documents, regulatory materials, analysis plans and outputs, and Clinical Study Reports.
· Extensive experience with clinical and safety data review, interpretation of integrated evidence, and preparation of decision-quality recommendations for governance and senior leadership.
· Proven ability to influence and deliver at senior leadership level, internally and externally, and to lead effectively across functions without direct authority.
· Strong collaborative communication, problem solving, issue management, and conflict-navigation skills, with a solution-focused and accountable approach.
· Working knowledge of ICH-GCP, inspection readiness, global health-authority expectations, and clinical quality systems.
· Ability to manage multiple priorities, make sound judgments with incomplete information, and maintain a high standard of scientific and operational quality.
- undefined
Essential Qualifications and Experience
· Clinical development expertise in one or more immunology disease areas and experience with innovative therapeutic modalities, including cell therapy, biologics, or other advanced therapies.
· Experience leading a discipline, skill group, community of practice, or departmental capability initiative.
· Experience with portfolio planning, departmental resource management, operating-model design, or delivery of functional scorecard objectives.
· Experience leading external alliances or collaborations with academic institutions, investigators, consortia, service providers, CROs, or strategic partners.
· Understanding of translational medicine, biomarkers, clinical pharmacology, biostatistics, data science, safety, regulatory, CMC, and commercial considerations across the development lifecycle.
· External scientific credibility demonstrated through publications, presentations, professional networks, or recognized contribution to the field.
· Familiarity with clinical review and analytics tools including AI and with data-analysis environments
· Ability to travel nationally and internationally as required.
The annual base pay for this position ranges from $233,586.40 - $350,379.60 USD. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
People leadership, resource management and functional capability
· Line manage Clinical Scientists across recruitment, onboarding, objectives, performance, succession, career development, retention, and project and study allocation.
· Build an inclusive, high-performing team through clear expectations, feedback, coaching, mentorship, development plans, and appropriate delegation and oversight.
· Balance portfolio demand, capability, development opportunities, and business priorities; anticipate capacity and skill gaps and propose practical resourcing solutions.
· Contribute to departmental leadership, operating-model decisions, talent and resource reviews, issue resolution, and non-drug scorecard priorities; may serve as Clinical Science Skills Lead, strengthening procedures, training, communities of practice, and continuous improvement in quality, consistency, efficiency, and inspection readiness.
Portfolio, program and cross-functional leadership
· Provide portfolio-level Clinical Science insight to prioritize work, connect evidence needs across programs, and guide transparent trade-offs and resource decisions.
· Partner Lead with Clinical team to lead to shape strategy and execution; lead or support the Clinical Development Plan in alignment with the Target Product Profile, disease strategy, patient needs, and emerging evidence.
· Influence Global Project Teams and senior governance through evidence-based recommendations that clarify uncertainties, benefit-risk, operational implications, and decision points; resolve cross-functional issues and lead or support external alliances with clear expectations, governance, and risk management.
Clinical development, evidence generation and scientific leadership
· Lead clinical study design and delivery aligned with the Clinical Development Plan, ensuring objectives, endpoints, estimands, assessments, and operational choices generate decision-enabling evidence.
· Lead or provide senior review of strategic study documents and translate protocol intent into practical site and data-collection workflows; guide study teams and external partners through clear cross-functional accountabilities and risk-based oversight.
· Oversee clinical data review, eligibility, data cleaning, and analysis readiness; ensure traceability from endpoints to outputs and integrate efficacy, safety, PK/PD, biomarker, and translational evidence into clear recommendations with the responsible Physician or Clinical Lead.
· Partner with the Study Physician and Pharmacovigilance on safety surveillance, reconciliation, aggregate trends, and safety-review materials; escalate findings requiring medical judgment and ensure documented issue closure, regulatory compliance, and inspection readiness.
· Lead or review Clinical Science contributions to regulatory submissions, health-authority interactions, publications, and scientific disclosures; maintain consistency across outputs, translate external developments into strategy, and represent Clinical Science with external stakeholders.
Pay and benefits
$233,586 – $350,380 a year
Employer providedQualified retirement programs
Paid time off
Health coverage
Dental coverage
Vision coverage
Short-term incentive bonuses
Where you'll work
Cambridge, MAOn-siteOpen in Maps (opens in a new tab)
More jobs in Cambridge, MAJob intelligence
The context around this role
Live data · November 11, 2026
Salary intelligence
How the pay compares
This role's midpoint is 3% below the US median for Clinical Development roles at this level.
This roleEmployer provided
Director roles in Massachusetts66 roles publishing pay
Director roles in the US224 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $233,586 | — | $350,380 |
| Massachusetts (middle half) | $253,500 | $298,500 | $322,625 |
| All US (middle half) | $255,000 | $300,000 | $335,500 |
This role: AstraZeneca's own published range. Comparisons: the base pay employers published on open Clinical Development roles at the same level on Regulatory Jobs, November 11, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Development
The general path across 296 open Clinical Development roles on Regulatory Jobs, with the titles they carry most. Not AstraZeneca's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 37 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Collaboration and leadership17
- Documentation and SOPs6
- Clinical trial conduct6
- GMP and compliance4
- Quality systems and risk3
- Investigations and CAPA2
- Lab testing and methods1
- Validation and qualification1
- Regulatory submissions1
- Data and digital systems1
Regulatory intelligence
The rules, regulations and standards behind this role
The regulations, guidance and standards that govern Clinical Development work in pharmaceuticals, led by the one this posting names, each linked to the agency or standards body that publishes it.
- ICHICH E6(R3) good clinical practice(official source, opens in a new tab)The international standard for the design, conduct and reporting of clinical trialsNamed in the posting
- FDA21 CFR Part 312(official source, opens in a new tab)Investigational New Drug applications and sponsor duties in drug trials
- FDA21 CFR Part 50(official source, opens in a new tab)Protection of human subjects: informed consent in FDA-regulated trials
- FDA21 CFR Part 56(official source, opens in a new tab)Institutional review boards for FDA-regulated clinical investigations
- ICHICH E8(R1)(official source, opens in a new tab)General considerations for clinical studies and quality by design in trials
- ICHICH E9 and E9(R1)(official source, opens in a new tab)Statistical principles for clinical trials and estimands
- ICHICH E2A to E2F(official source, opens in a new tab)Clinical safety data management, expedited reporting and periodic safety reports
- ICHICH E3(official source, opens in a new tab)Structure and content of clinical study reports
- FDAFDA Investigations Operations Manual(official source, opens in a new tab)How FDA investigators plan and conduct inspections
- EUEU Clinical Trials Regulation 536/2014(official source, opens in a new tab)How clinical trials of medicines are authorized and run in the EU, through CTIS
- HHS45 CFR Part 46 (Common Rule)(official source, opens in a new tab)The federal policy for the protection of human research subjects
- NIH42 CFR Part 11(official source, opens in a new tab)Clinical trial registration and results reporting on ClinicalTrials.gov
- FDAFDA Bioresearch Monitoring (BIMO)(official source, opens in a new tab)FDA inspections of clinical investigators, sponsors, IRBs and GLP labs
- FDA21 CFR Part 11(official source, opens in a new tab)FDA rules for electronic records and electronic signatures
- HHSHIPAA Privacy Rule(official source, opens in a new tab)Federal protections for individually identifiable health information
- EUGDPR (Regulation 2016/679)(official source, opens in a new tab)The EU General Data Protection Regulation for personal data, including health data
Company hiring pulse
AstraZeneca on Regulatory Jobs
- 43
- Open roles
- 43
- Distinct roles
- 9
- Locations
By discipline
- Clinical18 42%
- Quality13 30%
- Regulatory12 28%
By level
- Director27 63%
- Associate & Specialist12 28%
- Senior & Principal2 5%
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Senior Group Director, Clinical Scientist - Immunology at AstraZeneca
Applications close November 30. $234K–$350K a year, employer provided.


