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New · posted Oct 31

Madrigal Pharmaceuticals · Pharmaceuticals

Senior Director, Global Safety Physician

  • Waltham, MA
  • On-site
  • Full-time
  • Director
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EmploymentFull-time
DeadlineOpen until filled

The role

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

What you need

Educational & Experience

  • MD or equivalent medical degree with licensure or eligibility for licensure

  • 15+ years of combined, relevant experience in industry, clinical safety, pharmacovigilance, or related roles within biotech / pharma

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. 

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].

Experience and Professional Qualifications

The applicant should be a dynamic leader who thrives within a fast-paced, growing, and collaborative, publicly owned biopharmaceutical company:

  • Deep knowledge of GCP, ICH E2E, GVP modules, and global regulatory safety expectations

  • Proven track record of leadership across phase I-IV studies and familiarity with post-marketing surveillance processes

  • Experience with safety database systems (e.g. Argus, ArisGlobal), MedDRA, and safety signal detection tools

  • Experience in a matrixed global environment

  • Specialty training in relevant therapeutic areas a plus

  • Excellent strategic thinking, problem-solving, and influencing skills

  • Deep knowledge of FDA, EMA, PMDA and other regulatory body interaction

The ideal candidate displays the following professional competenciesnice to have

  • Senior-level leadership and communication skills

  • Strategic thinker with deep scientific and regulatory knowledge

  • Sound judgment in risk-benefit evaluation

  • Ability to make decisions in uncertainty

  • Ability to influence and align cross-functional stakeholders at all levels

  • Ability to deliver executive briefings and board-level updates

  • Ability to anticipate and resolve problems effectively

  • Strong verbal communication and technical writing skills

  • Ability to present clearly using scientific and regulatory terminology

  • Fluent in English language

What you'll do

The Senior Director, Global Safety Physician plays a key role in ensuring patient safety in clinical studies and those receiving marketed products. This role is responsible for continuous assessment of safety data, signal detection, and benefit-risk evaluation for assigned compounds in development and in the postmarketing setting. The role requires strong collaboration within Global Clinical Safety and Pharmacovigilance and across Clinical Development, Regulatory Affairs, Biostats, and Clinical Operations, with leadership and key contributions to regulatory filings and global safety governance activities.

The Senior Director will serve as a medical expert for safety matters, supporting both investigational and marketed products. Additionally, the role will lead clinical safety strategy, author and review safety-related documents and responses to health authority queries, and support regulatory interactions.

Medical Oversight & Signal Management

  • Provide medical oversight for clinical safety signals, including review and interpretation of safety data from clinical trials, spontaneous reports, and literature.

  • Lead or participate in safety signal detection, evaluation, validation, and documentation in collaboration with safety scientists and other stakeholders.

  • Serve as a key member or chair of Safety Management Teams (SMTs), contributing to benefit–risk assessments and mitigation strategies.

Regulatory & Scientific Contributions

  • Author or medically review safety content in critical regulatory documents such as:

    • DSURs, PBRERs, RMPs, IBs, and safety sections of clinical study reports

  • Provide expert medical input for regulatory filings and interactions, including INDs, NDAs/BLAs, and safety responses to agency queries.

  • Support inspection readiness and audit activities related to clinical safety documentation.

Cross-functional Collaboration

  • Partner with Clinical Development, Biostats, and Regulatory Affairs to align on safety strategy and ensure scientifically sound decision-making.

  • Collaborate with PV Operations, Safety Data Management, and Medical Review teams to ensure quality and consistency in safety case evaluations.

  • Participate in internal governance forums such as Safety Review Committees (SRCs) or benefit–risk assessment boards.

Pay and benefits

$318,000 – $388,000 a year

Employer provided
How this compares

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $318,000 - $388,000 per year.

  • Equity

  • Bonus

  • Flexible paid time off

  • Medical, dental, vision and life/disability insurance

  • 401(k) with employer match

  • Employee Assistance Program

Where you'll work

Waltham, MAOn-siteOpen in Maps (opens in a new tab)

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Equal opportunity, accessibility and legal noticesMadrigal Pharmaceuticals's statements, word for word

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected].

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Job intelligence

The context around this role

Live data · October 31, 2026

Salary intelligence

How the pay compares

This role's midpoint is 36% above the US median for Clinical Safety & Pharmacovigilance roles at this level.

This roleEmployer provided

$318,000 to $388,000 a year

Director roles in Massachusetts24 roles publishing pay

Middle half $217,500 to $281,000, median $229,000

Director roles in the US69 roles publishing pay

Middle half $213,500 to $281,000, median $260,000
Annual base pay
Annual base payLowMedianHigh
This role$318,000—$388,000
Massachusetts$217,500$229,000$281,000
All US$213,500$260,000$281,000

This role: Madrigal Pharmaceuticals's own published range. Comparisons: the base pay employers published on open Clinical Safety & Pharmacovigilance roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.

Career trajectory

Where this role sits in Clinical Safety & Pharmacovigilance

The general path across 113 open Clinical Safety & Pharmacovigilance roles on Regulatory Jobs, with the titles they carry most. Not Madrigal's own promotion track.

  1. Earlier

    Associate & Specialist

    Often: Associate, Pharmacovigilance Operations/Drug Safety · Clinical Sciences Partnership COE Coordinator

  2. Earlier

    Senior & Principal

    Often: Senior Safety Scientist · Clinical FSP Quality Manager

    $186K median11 open
  3. One step back

    Manager

    Often: Senior Manager, Clinical Quality Assurance · Clinical FSP Quality Manager

    $170K median15 open
  4. This role

    Director

    Often: Director · Senior Medical Director

    $260K median70 open
  5. Next step

    VP & Executive

    Often: Head of Multiple Myeloma & AML, Oncology · Head of Patient-Facing Quality Assurance

    $347K median12 open

Skills DNA

What this role leans on

How many of the posting's 40 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.

GMP and compliance: 2 linesDocumentation and SOPs: 8 linesInvestigations and CAPA: 1 lineValidation and qualification: 1 lineRegulatory submissions: 2 linesQuality systems and risk: 2 linesData and digital systems: 1 lineClinical trial conduct: 4 linesCollaboration and leadership: 13 linesGMPDocumentationInvestigationsValidationSubmissionsQuality systemsData systemsClinical trialsTeamwork
  • Collaboration and leadership13
  • Documentation and SOPs8
  • Clinical trial conduct4
  • GMP and compliance2
  • Regulatory submissions2
  • Quality systems and risk2
  • Investigations and CAPA1
  • Validation and qualification1
  • Data and digital systems1

Company hiring pulse

Madrigal on Regulatory Jobs

12
Open roles
12
Distinct roles
3
Locations

By discipline

  • Clinical7 58%
  • Quality3 25%
  • Regulatory2 17%

By level

  • Director10 83%
  • VP & Executive1 8%
  • Manager1 8%
See all 12 Madrigal roles

More roles at Madrigal

All 12 Madrigal roles

Similar Clinical Safety & Pharmacovigilance roles elsewhere

Senior Director, Global Safety Physician at Madrigal

Open until filled. $318K–$388K a year, employer provided.

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