

New · posted Oct 31
Relay Therapeutics · Biotechnology
Medical Director/Senior Medical Director, Patient Safety & Risk Management
- Cambridge, MA
- On-site
- Full-time
- Director
The role
The Medical Director, Patient Safety & Risk Management at Relay Therapeutics will serve as the Global Medical Safety Lead (GSL) and provides strategic and medical leadership for the safety surveillance and risk management of Relay Therapeutic assigned products throughout the product lifecycle. This role is responsible for the evaluation, interpretation, and communication of safety information; signal detection and management; benefit-risk assessment; and development of risk minimization strategies to ensure patient safety and regulatory compliance. In addition, the GSL will support the medical review of individual case safety reports and safety surveillance activities as needed for assigned Relay Therapeutic products. The GSL will lead the cross functional Safety Management Team in the evaluation of safety signals and implementation of risk minimization activities for Relay Therapeutic products.
We are seeking a safety physician, who thrives in a dynamic, agile biotech environment. Reporting to the Executive Director, Patient Safety & Risk Management, this individual serve as a key collaborator and leader in cross functional clinical program teams, including Clinical Development, Clinical Operations, Biostats, Data Management and Regulatory Affairs. The successful candidate will play a critical role in advancing the development of transformative therapies by providing medical safety expertise.
What you need
Skills named in this posting
- MD or DO with residency or clinical experience
- 7-10 years drug safety experience in pharma
- Aggregate safety reports (DSUR, PBRER/PSUR)
- Risk management planning (RMP, REMS)
- Signal detection and benefit-risk assessment
- Global safety surveillance regulations
- Leading cross-functional teams
- NDA/ISS drafting and review
What you'll do
Your Role
- Direct the planning, preparation, writing and review of safety aggregate reports, including DSUR.
- Train/collaborate and support qualified PSRM staff on medical review, safety surveillance activities and authoring of aggregate reports.
- Provide benefit-risk assessment on potential safety signal or in safety documents/reports and leads product benefit-risk assessment discussions at safety management meetings.
- Lead cross functional safety management team meetings and escalate safety issues including preparing and presenting of safety issue and recommendation to the executive decision-making body.
- Contribute to the development of Investigator Brochures, Protocols, Subject Informed Consent, statistical analysis plans, integrated safety summary, RMP/REMS, and other study related documents
- Support and collaborate with cross functional teams on safety related activities including providing responses to safety related queries from regulatory authorities and IRB/EC.
- Ensure compliance with regulatory guidelines and internal processes and procedures, to be inspection ready and serve as SME in audits and inspections.
- Serve as back-up medical review/sponsor approval of ICSRs and ensure appropriate medical evaluation of individual case safety reports and emerging safety trends.
Pay
$201,000 – $351,000 a year
Employer providedYour Background
- MD, DO or medical degree from an accredited medical school and completion of an accredited medical or surgical residency or clinical experience in either academic setting or private practice
- A minimum of drug safety experience 7-10 years in the pharmaceutical industry
- Experience leading cross functional teams and/or projects
- Expertise in analyzing and presenting complex medical-scientific data from broad range of sources required
- Experience providing medical leadership and strategic review of aggregate safety reports (DSUR, PBRER/PSUR) is required
- Knowledge of global risk management planning including RMPs, REMS (Risk Evaluation and Mitigation strategies) and risk minimization strategies required
- Expertise in global regulations governing safety surveillance and risk management
- Prior NDA filing (ISS drafting and review) experience strongly preferred
Estimated Salary Range: [$201,000 - $351,000].
The range provided above is based on what we believe to be a reasonable estimate for this job at the time of posting. Actual base salary will depend on a number of factors, including but not limited to, a candidate’s education, experience, skills and location.
Where you'll work
Cambridge, MAOn-siteOpen in Maps (opens in a new tab)
More jobs in Cambridge, MA
From the posting
About Relay Therapeutics
Relay Therapeutics is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process.
Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. If you’re excited by the challenge of putting protein motion at the heart of drug discovery and passionate about making a difference in the lives of patients, join us!
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 6% above the US median for Clinical Safety & Pharmacovigilance roles at this level.
This roleEmployer provided
Director roles in Massachusetts24 roles publishing pay
Director roles in the US69 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $201,000 | — | $351,000 |
| Massachusetts (middle half) | $217,500 | $229,000 | $281,000 |
| All US (middle half) | $213,500 | $260,000 | $281,000 |
This role: Relay Therapeutics's own published range. Comparisons: the base pay employers published on open Clinical Safety & Pharmacovigilance roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Safety & Pharmacovigilance
The general path across 113 open Clinical Safety & Pharmacovigilance roles on Regulatory Jobs, with the titles they carry most. Not Relay Therapeutics's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 10 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Documentation and SOPs7
- Collaboration and leadership6
- Quality systems and risk3
- Clinical trial conduct3
- GMP and compliance2
- Lab testing and methods1
- Investigations and CAPA1
- Data and digital systems1
- MD or DO with residency or clinical experience
- 7-10 years drug safety experience in pharma
- Aggregate safety reports (DSUR, PBRER/PSUR)
- Risk management planning (RMP, REMS)
- Signal detection and benefit-risk assessment
- Global safety surveillance regulations
- Leading cross-functional teams
- NDA/ISS drafting and review
Company hiring pulse
Relay Therapeutics on Regulatory Jobs
- 4
- Open roles
- 4
- Distinct roles
- 1
- Locations
By discipline
- Regulatory2 50%
- Clinical2 50%
By level
- Director3 75%
- Senior & Principal1 25%
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Medical Director/Senior Medical Director, Patient Safety & Risk Management at Relay Therapeutics
Open until filled. $201K–$351K a year, employer provided.

