New · posted Oct 31
Praxis Precision Medicines · Biotechnology
Senior Clinical Trial Manager (CTM)
- Remote, US
- Remote
- Full-time
- Manager
The role
This role will be responsible for project management in the initiation, execution and close out of domestic and international clinical studies, including study concept and design, feasibility assessments, study start-up, contract and budget oversight, data exchange and support of data analysis and interpretation.
This position requires both the knowledge and experience to work within established clinical trial paradigms while exploring and embracing new approaches to conducting research to support data aggregation and analysis to advance patient care. The Sr. CTM will participate on clinical project teams to achieve quality results in a cost-effective and timely manner. S/he will be a key team member to establish key practices and procedures for the clinical team.
What you need
Education and Professional Experience
- Bachelor’s degree in a scientific field required; advanced scientific degree a plus
- 5+ years directly managing clinical trials in Sponsor or CRO setting
- In-depth knowledge of clinical trial operations, ICH, GCP Guidelines and other applicable regulatory requirements
- Experience directing members of clinical operations teams
- Experience working in a team across multiple functional areas (e.g., Quality Assurance, Data Management, Biostats, Medical Writing, Safety, Clinical Supply, Finance)
What you'll do
- Manage study activities in the successful execution of clinical trials from protocol concept to clinical study report, complying with Good Clinical Practice (GCP) guidelines and international regulations
- Manage strategic engagement with key collaborators
- Set-up and oversee clinical trial-related trackers such as regulatory documents, trial master file (TMF), startup progress, screening/enrollment, study invoices/payments, project budgets, etc.
- Key contributor to IRB/EC and regulatory submissions
- Oversee TMF reviews to ensure completeness and inspection readiness
- Regularly review documents to ensure adherence to Clinical Operations and/or project specific quality requirements (e.g. SOPs, work practices, training guides)
- Identify and mitigate against study risks, escalating as necessary
- Direct initiatives to identify and implement best practices and continuous improvement plans in clinical development
Pay and benefits
$168,000 – $188,000 a year
Employer providedOther Essentials and Key Success Factors
- Intellectual curiosity, innovation and creative problem solving with an entrepreneurial spirit
- Ability to think critically in fast-paced projects with a keen sense of urgency and demonstrated ability to problem solve
- Self-motivated and able to work autonomously, as well as a member of a collaborative team
- Highly-organized and detail-oriented with a passion to deliver quality results
- Strong verbal and written communication skills with an ability to build relationships internally and externally
- Highest levels of professionalism, confidence, personal values and ethical standards
Annualized Base Salary
$168,000—$188,000 USD
Compensation & Benefits
At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!
Company Overview
99%
99% of medical, dental and vision premiums paid
Company-paid life insurance, AD&D and disability
6%
401(k) match up to 6%
Stock incentives and ESPP
Discretionary quarterly bonus
Generous PTO and paid holidays
Working conditions
Location: This position may be performed remotely with travel to the Boston area as needed.
Equal opportunity, accessibility and legal noticesPraxis Precision Medicines's statements, word for word
Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.
Diversity, Equity & Inclusion
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.
Attention: Job Scam Alert
Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to [email protected].
Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 10% above the US median for Clinical Trial Management roles at this level.
This roleEmployer provided
Manager roles in the US26 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $168,000 | — | $188,000 |
| All US (middle half) | $150,000 | $162,000 | $175,000 |
This role: Praxis Precision Medicines's own published range. Comparisons: the base pay employers published on open Clinical Trial Management roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Trial Management
The general path across 33 open Clinical Trial Management roles on Regulatory Jobs, with the titles they carry most. Not Praxis Precision Medicines's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 15 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Clinical trial conduct8
- Documentation and SOPs5
- Collaboration and leadership5
- GMP and compliance3
- Lab testing and methods1
- Regulatory submissions1
- Quality systems and risk1
- Data and digital systems1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
Company hiring pulse
Praxis Precision Medicines on Regulatory Jobs
- 8
- Open roles
- 8
- Distinct roles
- 1
- Locations
By discipline
- Clinical5 63%
- Regulatory2 25%
- Quality1 13%
By level
- Director5 63%
- VP & Executive1 13%
- Manager1 13%
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Senior Clinical Trial Manager (CTM) at Praxis Precision Medicines
Open until filled. $168K–$188K a year, employer provided.