New · posted Oct 31
Praxis Precision Medicines · Biotechnology
Clinical Development Leader, Lifecycle Management
- Remote, US
- Remote
- Full-time
- Director
The role
Turning scientific possibilities into meaningful opportunities for patients takes more than expertise. It takes breadth, sound judgment, and the drive to lead across programs, translating emerging data into decisions that move medicines forward. At Praxis, you’ll provide clinical leadership across lifecycle management activities and early-phase development throughout our pipeline. You’ll work across mechanisms, indications, and stages of development: shaping opportunities, leading early clinical work, interpreting emerging data, and turning scientific and clinical insights into development decisions. This is a role for someone who leads the work, not someone who primarily advises or reviews it. You’ll bring the breadth to move confidently across programs and the judgment to identify where clinical development can create the greatest value for patients.
What you need
Qualifications and Key Success Factors
- An advanced scientific degree (MD, PharmD, PhD, or equivalent) is required.
- A track record of clinical trials, programs, submissions, or major development decisions that you personally led.
- Regulatory submission ownership having carried the clinical content of IND, CTA, NDA, or MAA filings, briefing books, and health authority interactions.
- Strong judgment and the ability to make thoughtful, timely calls on emerging data with incomplete information and the knowledge of what to escalate and when.
- Comfort operating in a dynamic environment where priorities shift, scope evolves, and ownership matters more than rigid role boundaries.
- You’ll thrive here if you take ownership, challenge assumptions with scientific rigor, move with urgency without sacrificing quality, and stay focused on outcomes that matter for patients.
Annualized Base Salary
$280,000—$350,000 USD
Compensation & Benefits
At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!
Company Overview
What you'll do
- Lifecycle strategy: Identify and drive opportunities to expand the impact of late-stage and marketed assets, including new indications, label expansion, and formulation opportunities.
- Early development: Lead first-in-human and dose-escalation studies, applying PK/PD and emerging clinical data to dose selection, decision rules, and next-stage development.
- Clinical entry: Drive the clinical strategy and content for IND-enabling submissions and the decisions required to move programs into human studies.
- Pipeline-wide leadership: Work credibly across mechanisms, indications, and phases, quickly developing the context needed to make sound clinical development decisions.
- Data-driven decisions: Interpret emerging clinical and scientific data, identify what matters, and make timely calls when information is incomplete.
- Cross-functional and external leadership: Drive teams across clinical operations, biostatistics, regulatory, safety, translational sciences, and other disciplines, while representing Praxis credibly with investigators, KOLs, health authorities, and partners.
Pay and benefits
$280,000 – $350,000 a year
Employer provided99%
99% of medical, dental and vision premiums paid
Company-paid life insurance, AD&D and disability
6%
401(k) match up to 6%
Stock incentives and ESPP
Discretionary quarterly bonus
Generous PTO and paid holidays
Working conditions
Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed.
Equal opportunity, accessibility and legal noticesPraxis Precision Medicines's statements, word for word
The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.
Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.
Diversity, Equity & Inclusion
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.
Attention: Job Scam Alert
Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to [email protected].
Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 6% above the US median for Clinical Development roles at this level.
This roleEmployer provided
Director roles in the US93 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $280,000 | — | $350,000 |
| All US (middle half) | $258,000 | $298,000 | $318,500 |
This role: Praxis Precision Medicines's own published range. Comparisons: the base pay employers published on open Clinical Development roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Development
The general path across 116 open Clinical Development roles on Regulatory Jobs, with the titles they carry most. Not Praxis Precision Medicines's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 16 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Collaboration and leadership5
- Regulatory submissions4
- Clinical trial conduct4
- Documentation and SOPs1
- Investigations and CAPA1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
Company hiring pulse
Praxis Precision Medicines on Regulatory Jobs
- 8
- Open roles
- 8
- Distinct roles
- 1
- Locations
By discipline
- Clinical5 63%
- Regulatory2 25%
- Quality1 13%
By level
- Director5 63%
- VP & Executive1 13%
- Manager1 13%
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Clinical Development Leader, Lifecycle Management at Praxis Precision Medicines
Open until filled. $280K–$350K a year, employer provided.

