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New · posted Oct 31

Korro Bio · Biotechnology

Senior Clinical Trial Manager

  • Cambridge, MA
  • Hybrid
  • Full-time
  • Manager
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Pay$163K–$187K
EmploymentFull-time
LocationCambridge, MA
LevelManager
FunctionClinical Trial Management
DeadlineOpen until filled

The role

The successful candidate will have a strong background leading early phase clinical trials. This individual will use outstanding cross-functional skills to achieve study and program goals and will develop a solid understanding of the clinical indications being pursued including knowledge of the patient needs, development plan, applicable regulatory guidance as well as the competitive landscape in the therapeutic space.

Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro’s lead program is for Urea Cycle Disorders. Korro is based in Cambridge, Massachusetts. For more information, visit korrobio.com.

We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.

What you need

Required Qualifications

  • Bachelor’s Degree; Life Sciences preferred. Advanced degree desirable.
  • 8+ years of relevant clinical development and operations experience, in clinical operations leadership roles, leading global clinical studies/programs, with track records of initiating and delivering early phase trials
  • Experience in rare diseases and early phase studies (including FIH studies) is highly desirable
  • Strong leadership skills driving large cross functional teams
  • Deep knowledge of global regulatory and compliance requirements for clinical research, local country requirements and ICH GCP, including experience with global regulatory inspections
  • Excellent critical and strategic thinking, with strong ability to understand the big picture as well as the important details that may impact the big picture
  • Global clinical operations & development experience across therapeutic areas with demonstrated ability to rapidly learn new indications
  • Excellent communicator and influencer, able to persuasively convey ideas and data, verbally and in writing

    • Korro Bio offers a competitive total rewards package, including equity-based compensation and comprehensive benefits: medical, dental, and vision coverage; 401(k) retirement plan; life insurance; dependent care flexible spending account; company-funded health savings account; and complimentary parking or a MBTA commuter pass.

    Skills named in this posting

    What you'll do

  • Plan, drive and oversee all aspects of multi-center global clinical trials in compliance with GCPs, SOPs, and within designated program budgets and timelines in close collaborations with key stakeholders and Clinical Research Organizations (CROs)
  • Drive implementation of clinical operational strategy for successful delivery of assigned clinical studies
  • Use operational and therapeutic expertise to optimize trial design and execution and collaborate with the study team to accelerate clinical trial timelines
  • Provide oversight and management for all relevant CROs and vendors including contracting and clinical budgets; develop contingency plans for clinical trials
  • Coordinate and lead study team meetings and update the Program Team on timelines and milestones for the study
  • Contribute to the development of study documentation including protocol review, creating study plans, ICFs, and designing CRFs
  • Contribute to CRO/vendors identification, qualification and selection processes as applicable
  • Participate in study site selection; review and update site specific consent forms; track patient accrual and study progress via standard reports; assure patient eligibility; document protocol deviations/violations; and manage adverse event reporting
  • Oversee clinical monitoring from site qualification to site closure visits and assure integrity of clinical data with respect to accuracy, accountability and documentation through review of case report forms, source documents, and medical records. Evaluate and analyze clinical data
  • Oversee high quality implementation, execution and delivery of studies by CROs in alignment with timeline and budget plan
  • Establish an open team culture defined by transparent communication, clear goal setting, and risk-based oversight
  • Ensure compliance with internal policies and procedures, GCPs, and applicable regulations; ensure inspection readiness
  • Oversee Vendor Contracts and Clinical Study Budget, report progress to finance team
  • Provide input to Clinical Study Reports and Investigator Brochures, including data cleaning, listing review, and report writing
  • Oversee TMF management and review TMF documentation as necessary
  • Limited travel possible to field sites to supervise and/or monitor clinical studies (<25%)

    • Pay and benefits

    $163,000 – $187,000 a year

    Employer provided
    How this compares

    • Equity-based compensation

    • Medical, dental, and vision coverage

    • 401(k) retirement plan

    • Life insurance

    • Company-funded health savings account

    • Complimentary parking or MBTA commuter pass

    Where you'll work

    Cambridge, MAHybridOpen in Maps (opens in a new tab)

    More jobs in Cambridge, MA

    Job intelligence

    The context around this role

    Live data · October 31, 2026

    Salary intelligence

    How the pay compares

    This role's midpoint is 8% above the US median for Clinical Trial Management roles at this level.

    This roleEmployer provided

    $163,000 to $187,000 a year

    Manager roles in Massachusetts6 roles publishing pay

    Middle half $155,500 to $176,500, median $175,000

    Manager roles in the US26 roles publishing pay

    Middle half $150,000 to $175,000, median $162,000
    Annual base pay
    Annual base payLowMedianHigh
    This role$163,000—$187,000
    Massachusetts$155,500$175,000$176,500
    All US$150,000$162,000$175,000

    This role: Korro Bio's own published range. Comparisons: the base pay employers published on open Clinical Trial Management roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.

    Career trajectory

    Where this role sits in Clinical Trial Management

    The general path across 33 open Clinical Trial Management roles on Regulatory Jobs, with the titles they carry most. Not Korro Bio's own promotion track.

    1. Earlier

      Associate & Specialist

      Often: Clinical Trial Assistant

      1 open

    2. One step back

      Senior & Principal

      Often: Senior Clinical Trial Associate · Senior Clinical Trial Leader

      2 open

    3. This role

      Manager

      Often: Senior Clinical Trial Manager · Clinical Trial Manager

      $162K median29 open

    4. Next step

      Director

      Often: Associate Director, Clinical Development Trial Lead

      1 open

    Skills DNA

    What this role leans on

    How many of the posting's 6 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.

    GMP and compliance: 2 linesDocumentation and SOPs: 2 linesInvestigations and CAPA: 1 lineValidation and qualification: 1 lineClinical trial conduct: 3 linesCollaboration and leadership: 5 linesGMPDocumentationInvestigationsValidationClinical trialsTeamwork
    • Collaboration and leadership5
    • Clinical trial conduct3
    • GMP and compliance2
    • Documentation and SOPs2
    • Investigations and CAPA1
    • Validation and qualification1

    Regulatory intelligence

    The rules behind this role

    Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.

    From Regulatory News

    Company hiring pulse

    Korro Bio on Regulatory Jobs

    2
    Open roles
    2
    Distinct roles
    1
    Locations
    See all 2 Korro Bio roles

    More roles at Korro Bio

    Similar Clinical Trial Management roles elsewhere

    Senior Clinical Trial Manager at Korro Bio

    Open until filled. $163K–$187K a year, employer provided.

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