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New · posted Oct 31

Orca Bio · Biotechnology

Medical Director / Senior Medical Director, Clinical Development

  • Menlo Park, CA
  • On-site
  • Full-time
  • Director
Save
EmploymentFull-time
DeadlineOpen until filled

The role

More than one million people in the United States today are fighting blood cancer. While a traditional allogeneic stem cell transplant has been the best hope for many, the transplant itself can prove fatal or lead to serious conditions, such as graft vs. host disease. Orca Bio is a commercial-stage biotechnology company redefining the transplant process by developing next-generation cell therapies with the goal of providing significantly better survival rates with dramatically fewer risks. With our purified, high-precision cell therapies we hope to not only replace patients' blood and immune systems with healthy ones, but also restore their lives.

Position Summary: We are seeking a Medical Director / Senior Medical Director (depending on experience) to serve as medical lead for our next-generation cell therapy program (Orca-Q) late-stage study. This role is critical in conceptualizing our Pivotal Phase 3 study, developing the associated protocols, analyzing data, and conducting the clinical trial. The candidate must work collaboratively within Orca Bio and also with principal investigators (PIs) nationwide to progress the program towards product registration.  

What you need

  • MD required; preferably a trained bone marrow transplant (BMT) physician, hematologist and/or oncologist.
  • 3+ years of industry experience and expertise in cell therapy, BMT, or immune disorders preferred, including experience implementing randomized registrational studies.
  • Self starter with an entrepreneurial mindset.
  • Strong project management skills, with the ability to handle multiple priorities and timelines, work independently and drive initiatives.
  • Excellent verbal and written communication skills, with the ability to engage and motivate clinical site teams.
  • Willingness to travel as needed to meet with clinical sites and stakeholders.
  • The anticipated annual salary range (listed above) for this job is based on prior experience in the role/industry, education, location, internal equity, and other job-related factors as permitted by law. For remote-based positions, this range may vary based on your local market. Full-time employment positions will also be eligible to receive pre-IPO equity and annual bonus, in addition to competitive medical, dental, and vision benefits, PTO, 401(k) plan, life and accidental death and disability coverage, and parental leave benefits. Other perks include subsidized daily lunches and snacks at our on-site locations.

    What you'll do

  • Support strategic planning and execution of clinical strategy.
  • Develop clinical trial protocols, statistical analysis plans, investigator brochures, and other documentation for clinical trials.
  • Develop and present CRA/site training materials and present at Investigator Meetings/site initiation visits as required.
  • Provide leadership to Clinical Trial Manager (CTM), Clinical Research Associates (CRA) and Clinical Scientists dedicated to the program.
  • Medical monitoring, review, and analysis.
  • Interpret early- and late-stage clinical data and continuously assess preclinical, clinical, and scientific literature to inform clinical strategy and ensure positive benefit-risk profile for assigned programs in collaboration with key stakeholders.
  • Collaborate with Regulatory, Operations, Drug Safety, Medical and other teams to provide oversight, prepare reports, and ensure all milestones are met.
  • Work collaboratively with all internal and external stakeholders.
  • Pay and benefits

    $225,000 – $325,000 a year

    Employer provided
    How this compares
    • Pre-IPO equity

    • Annual bonus

    • Medical, dental and vision

    • PTO

    • 401(k) plan

    • Parental leave

    Where you'll work

    Menlo Park, CAOn-siteOpen in Maps (opens in a new tab)

    More jobs in Menlo Park, CA
    Dozens of Orca Bio colleagues in hard hats and safety vests waving inside a large manufacturing space

    From the posting

    About Orca Bio

    We are driven by a passion for science and compassion for patients. We act with urgency to ensure our treatments are one day accessible to all who need them.

    We live by our core values of passion, courage, and integrity. Excellence in our work means the chance to unlock a better quality of life for our patients, and with that comes tremendous responsibility.

    We innovate on a path that hasn’t been paved. We embrace an entrepreneurial spirit and take calculated risks to achieve our mission. We aren’t afraid to ask “why not” and challenge the status quo.

    We maintain a start-up culture of camaraderie and leadership by example, regardless of title.

    Orca Bio company page · 6 open roles
    Equal opportunity, accessibility and legal noticesOrca Bio's statements, word for word

    Notice to staffing firms

    Orca Bio does not accept resumes from staffing agencies with which we do not have a written agreement and specific engagement for a particular opening. Our employment activities, inquiries and offers are managed through our HR/Talent team, and all candidates are presented through this channel only. We do not accept unsolicited resumes, and we rarely outsource recruitment.

    We’re proud to be an equal opportunity employer, and recognize that celebrating our differences creates stronger, lasting solutions that better serve our team, our patients and their healthcare providers.

    Job intelligence

    The context around this role

    Live data · October 31, 2026

    Salary intelligence

    How the pay compares

    This role's midpoint is 8% below the US median for Clinical Development roles at this level.

    This roleEmployer provided

    $225,000 to $325,000 a year

    Director roles in California21 roles publishing pay

    Middle half $244,000 to $339,000, median $295,000

    Director roles in the US93 roles publishing pay

    Middle half $258,000 to $318,500, median $298,000
    Annual base pay
    Annual base payLowMedianHigh
    This role$225,000—$325,000
    California$244,000$295,000$339,000
    All US$258,000$298,000$318,500

    This role: Orca Bio's own published range. Comparisons: the base pay employers published on open Clinical Development roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.

    Career trajectory

    Where this role sits in Clinical Development

    The general path across 116 open Clinical Development roles on Regulatory Jobs, with the titles they carry most. Not Orca Bio's own promotion track.

    1. Earlier

      Associate & Specialist

      Often: Summer Intern

    2. Earlier

      Senior & Principal

      Often: Clinical Scientist · Clinical Scientist/Sr. Clinical Scientist, Oncology

    3. One step back

      Manager

      Often: Manager, Aesthetics Clinical Development · Senior Manager, Clinical Scientist

    4. This role

      Director

      Often: Senior Director, Clinical Development · Executive Medical Director, Oncology Clinical Development

      $298K median96 open
    5. Next step

      VP & Executive

      Often: Vice President, Clinical Development · Associate Vice President

      $360K median11 open

    Skills DNA

    What this role leans on

    How many of the posting's 5 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.

    Documentation and SOPs: 1 lineInvestigations and CAPA: 2 linesClinical trial conduct: 2 linesCollaboration and leadership: 4 linesDocumentationInvestigationsClinical trialsTeamwork
    • Collaboration and leadership4
    • Investigations and CAPA2
    • Clinical trial conduct2
    • Documentation and SOPs1

    Company hiring pulse

    Orca Bio on Regulatory Jobs

    6
    Open roles
    6
    Distinct roles
    4
    Locations

    By discipline

    • Clinical4 67%
    • Regulatory1 17%
    • Quality1 17%

    By level

    • Director3 50%
    • Associate & Specialist2 33%
    • Manager1 17%
    See all 6 Orca Bio roles

    More roles at Orca Bio

    All 6 Orca Bio roles

    Similar Clinical Development roles elsewhere

    Medical Director / Senior Medical Director, Clinical Development at Orca Bio

    Open until filled. $225K–$325K a year, employer provided.

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