New · posted Nov 6
Roche · Pharmaceuticals
Head, US Patient Safety
- South San Francisco, CA
- On-site
- Full-time
- VP & Executive
The role
The Head of US Patient Safety is accountable for the overall strategic direction, operational execution, and holistic performance of the PV system for the USA, ensuring full alignment with International Patient Safety (IPS) priorities and business needs. Operating in close partnership with Genentech, the Head of US Patient Safety serves as the primary steward of the affiliate PV system and safety risk management.
In this role, core responsibilities will include:
- Strategy: Lead the Affiliate Patient Safety strategy, collaborating with cross-functional leaders to prioritize initiatives that maximize patient and business impact. Additionally, serve on the IPS Leadership Team to co-own the strategic vision, governance, and collective performance of the broader IPS organization.
- PV System: Maintain holistic oversight of the local PV system to ensure strict compliance, operational efficiency, and inspection readiness, thereby safeguarding the company’s license to operate.
- Safety Risk Management: Ensure product safety launch readiness, aligning global safety solutions with therapeutic strategies and driving local risk minimization efforts that improve patient outcomes.
- Safety Communication: Lead strategies to communicate and educate on safety risks in context, ensuring transparent and timely safety communications to healthcare professionals, patients, and external stakeholders, in partnership with US Medical and other functions.
- Safety Insights: Drive the systematic collection, analysis, and sharing of safety insights aligned with disease area goals, leveraging digital solutions and real-world evidence as appropriate.
- People Leadership & Talent Pipeline: Provide solid-line leadership to the US Patient Safety Leadership Team, with overarching talent oversight, succession planning, and capability building across all US safety staff.
What you need
- Medical degree (MD or equivalent) or higher degree in life science discipline (e.g., PharmD, PhD, MSc)
- Minimum of 12 years of experience in PV, clinical research/development, including 7+ years in senior Patient Safety leadership roles across complex regional or global environments.
- Minimum of 7 years of executive people leadership coaching, developing, and engaging large multi-layered teams and networks of leaders.
- Proven track record of operating with an enterprise-first mindset, demonstrating behaviors that consistently drive impact, influence strategy, and build capabilities beyond assigned regional borders.
- Executive presence and recognized authority influencing senior leadership across local and global organizations.
- Extensive experience engaging with major Tier-1 global Health Authorities and shaping international PV ecosystems
Relocation benefits are available for this posting
The expected salary range for this position based on the primary location of California is $282,000 - $523,600. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Pay
$282,000 – $523,600 a year
Employer providedWhere pay transparency applies, details are provided based on the primary posting location. For this role, the primary location is South San Francisco. If you are interested in additional locations where the role may be available, we will provide the relevant compensation details later in the hiring process.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Where you'll work
South San Francisco, CAOn-siteOpen in Maps (opens in a new tab)
More jobs in South San Francisco, CAEqual opportunity, accessibility and legal noticesRoche's statements, word for word
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
Job intelligence
The context around this role
Live data · November 6, 2026
Salary intelligence
How the pay compares
This role's midpoint is 16% above the US median for Clinical Safety & Pharmacovigilance roles at this level.
This roleEmployer provided
VP & Executive roles in California5 roles publishing pay
VP & Executive roles in the US12 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $282,000 | — | $523,600 |
| California (middle half) | $346,500 | $347,500 | $403,000 |
| All US (middle half) | $346,500 | $347,000 | $384,250 |
This role: Roche's own published range. Comparisons: the base pay employers published on open Clinical Safety & Pharmacovigilance roles at the same level on Regulatory Jobs, November 6, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Safety & Pharmacovigilance
The general path across 163 open Clinical Safety & Pharmacovigilance roles on Regulatory Jobs, with the titles they carry most. Not Roche's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 16 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Collaboration and leadership6
- Quality systems and risk2
- GMP and compliance1
- Documentation and SOPs1
- Regulatory submissions1
- Clinical trial conduct1
Regulatory intelligence
The rules, regulations and standards behind this role
The regulations, guidance and standards that govern Clinical Safety & Pharmacovigilance work in pharmaceuticals, each linked to the agency or standards body that publishes it.
- FDA21 CFR 314.80 and 600.80(official source, opens in a new tab)Postmarketing reporting of adverse drug and biologic experiences
- ICHICH E2A to E2F(official source, opens in a new tab)Clinical safety data management, expedited reporting and periodic safety reports
- FDAFDA good pharmacovigilance practices(official source, opens in a new tab)Good Pharmacovigilance Practices and Pharmacoepidemiologic Assessment
- FDAFDA FAERS(official source, opens in a new tab)The FDA Adverse Event Reporting System for drugs and biologics
- FDAFDA Investigations Operations Manual(official source, opens in a new tab)How FDA investigators plan and conduct inspections
- EMAEU Good Pharmacovigilance Practices (GVP)(official source, opens in a new tab)EMA's modules for pharmacovigilance systems, signals and periodic reports
- ICHMedDRA(official source, opens in a new tab)The ICH medical terminology for coding adverse events and medical history
- FDAFDA REMS(official source, opens in a new tab)Risk Evaluation and Mitigation Strategies for drugs with serious safety concerns
- FDA21 CFR Part 312(official source, opens in a new tab)Investigational New Drug applications and sponsor duties in drug trials
- EUDirective 2001/83/EC(official source, opens in a new tab)The EU code for medicinal products for human use: authorization, labeling, pharmacovigilance
- ICHICH E6(R3) good clinical practice(official source, opens in a new tab)The international standard for the design, conduct and reporting of clinical trials
- FDA21 CFR Part 201(official source, opens in a new tab)FDA labeling requirements for drugs, including prescribing information
- FDA21 CFR Part 11(official source, opens in a new tab)FDA rules for electronic records and electronic signatures
- Health CanadaCanada Food and Drug Regulations(official source, opens in a new tab)Health Canada's regulations for drugs, including GMP (Part C, Division 2)
- MHRAUK MHRA(official source, opens in a new tab)The UK regulator of medicines and medical devices, including UKCA marking
- PMDAJapan PMDA(official source, opens in a new tab)Japan's Pharmaceuticals and Medical Devices Agency
From Regulatory News
Manufacturing and quality coverage for this professionCompany hiring pulse
Roche on Regulatory Jobs
- 6
- Open roles
- 6
- Distinct roles
- 4
- Locations
By discipline
- Regulatory3 50%
- Clinical2 33%
- Quality1 17%
By level
- VP & Executive2 33%
- Manager2 33%
- Senior & Principal2 33%
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Head, US Patient Safety at Roche
Open until filled. $282K–$524K a year, employer provided.