New · posted Nov 8
GSK · Pharmaceuticals
Executive Medical Director, Early Clinical Development Lead - Oncology - Lung & Head/Neck Cancers
- Upper Providence, PA +1 more
- Hybrid
- Full-time
- Director
The role
For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.
GSK Oncology Clinical Development is seeking a highly skilled and motivated Executive Medical Director, Oncology Early Clinical Development Lead (ECDL) to join our dynamic Oncology Research and Development team. In this role the successful candidate will create a strong link between Clinical Development and Pre-clinical/ Discovery teams to improve forward and reverse translation and, thereby, increase the success of our Oncology clinical portfolio. They will be responsible for leading a team of talented Oncology Early Clinical Development Medical Directors and Clinical Scientists who will design and execute early-phase clinical studies, as well as contribute to the translational research strategy for early phase clinical assets. This role offers a unique opportunity to bridge the gap between preclinical research and clinical development, ensuring the successful translation of innovative therapies from the lab to the clinic.
What you need
Basic Qualifications
- MD or equivalent medical degree required
- Clinical and research experience in lung cancer
- Documented experience as a physician scientist in the pharmaceutical industry or an academic oncology setting, with experience in oncology early phase clinical trials and translational research.
- Experience interpreting pre-clinical data packages and providing clinical recommendations on indication and patient selection
- Experience designing and executing early phase clinical studies, including FTIH and POC trials
- Experience in lung cancer treatment guidelines, therapeutic competitive landscape, clinical development process and drug approval process in major regions
- Experience developing and driving translational strategy: biomarker, companion diagnostic, PK/ PD modeling and simulation
- Experience managing direct reports and leading matrix teams
- Global regulatory experience
Clinical Data Interpretation, Clinical Trial Designs, Clinical Trials Monitoring, Digital Fluency, Drug Development, Drug Regulatory Affairs, Evidence Based Decision Making, Executive Presence, Hematology and Oncology, Learning Agility, Matrix Leadership, Real World Evidence (RWE), Scientific Presentations, Strategic Direction• If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $284,250 to $473,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Preferred Qualificationsnice to have
- MD or equivalent medical degree with PhD preferably in biological sciences or quantitative/computer science with documented application towards biomedical
What you'll do
Clinical Study Design & Execution
- Accountable for the clinical development plans (CDPs) for a portfolio of early phase (Phase I/II) clinical study protocols, including first-in-human (FIH) trials, dose-escalation/expansion studies, and proof-of-concept (POC) studies.
- Accountable for overall benefit:risk of a clinical program.
- Accountable for driving the end-to-end clinical development strategy and alignment to target medicine profiles (TMP) and integrated evidence plans (IEP), spanning all phases of development, including trial design, execution, and interpretation and delivery of trial results
- Leads clinical development discussions and teams at regulatory interactions and accountable for drafting clinical components of regulatory submissions/files (i.e. IND, NDA, BLA, MAA) including briefing documents, presentations, addressing questions and responses.
- Participate as a core member of the Early Development Team (EDT) and provide a single Clinical Development accountability at the program level within these teams and other cross-functional partnerships, e.g., with Medical Affairs, Integrated Evidence, Publications, and Global and Regional Commercial functions
- Ensure that all clinical studies are conducted in compliance with applicable regulatory requirements, Good Clinical Practice (GCP) guidelines, and GSK policies and procedures.
- Lead the cross-functional Early Clinical Matrix Team and provide clinical leadership, Oncology Clinical Development expertise, and customer insight for the program
Translational Research Strategy
- Oversee the development and execution of the clinical development components of the overall translational science strategy in partnership with Oncology Early Development Leaders, Oncology Translational Science, pre-clinical Oncology Research teams (ETCT & ITCT), AI/ML, Clinical Pharmacology & Experimental Medicine, Research Technologies
- Partner with the Oncology Tumor Teams (OTTs) to develop the translational strategy across assets within a given tumor and support OTT activities with a clinical and translational focus
- Drive advancements in translational research and emerging technologies to improve study designs and foster innovation
Data Analysis and Interpretation
- Interpret complex translational and clinical data and identify trends for clinical and regulatory documents consult on safety analyses, and responses to health authority queries
- Author and/or review abstracts, presentations and manuscripts for accuracy of clinical data, interpretation, and content.
- Prepare for and lead governance discussions in close collaboration with cross-functional Early Development or Medicine Development Team and other business lines
- Lead preparation of clinical sections of relevant regulatory filings (IND, study reports, NDA, annual reports, etc.)
- Lead and provide clinical support for investigator and consultant meetings (e.g., investigator meetings, clinical advisory boards)
- Present study results and translational insights to internal and external stakeholders, including senior management, scientific advisory boards, and regulatory agencies.
Collaboration and Communication
- As a therapy area subject matter expert, accountable for integrating inputs from across disciplines (research, clinical, medical, scientific, statistical, commercial, regulatory, manufacturing, operations, etc.) to ensure alignment and successful execution of translational research initiatives.
- Build and maintain strong relationships with key external experts (KEEs), academic collaborators, and external research organizations, including the Oncology Translational Network
- Collaborate with Principal Investigators and Steering Committees in the evaluation and assessment of publications (abstracts, posters, manuscripts) associated with clinical data.
- Serve as program medical experts for internal and external collaborators, investigators, and consultants
Oncology Clinical Development Leadership
- Lead, coach and mentor a team of Oncology Early Clinical Development Medical Directors and Clinical Scientists. Provide direct reports with ongoing coaching, development and leadership; includes holding regular staff meetings, check-ins and 1:1 meetings
- Guide direct reports to ensure cross-functional integration, coordination, collaboration, and alignment to enable effective and efficient CDP and translational strategy execution
- Foster the development of our culture within the team of direct reports: be bold, be swift, act with integrity, as a OneOncology community
- Contribute to the establishment of standards for clinical documents and data review processes across Oncology Clinical Development.
Pay and benefits
$284,250 – $473,750 a year
Employer providedHealth care and other insurance benefits
Retirement benefits
Paid holidays
Vacation
Paid caregiver/parental and medical leave
Annual bonus and long-term incentive program
Where you'll work
Upper Providence, PA +1 moreHybridOpen in Maps (opens in a new tab)
Also posted for: Waltham, MA
More jobs in Upper Providence, PA +1 moreWorking conditions
Work Arrangement
This role is hybrid. You will be on-site at one of the posted locations at least two days per week. Remote work is available on other days.
From the posting
About GSK
Business Introduction
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.
Find out more:
Our approach to R&D
Position Summary
Cancer is unrelenting, but so are we. At GSK, we are committed to transforming outcomes for people with cancer through innovative science, bold ambition, and strong partnerships across the healthcare ecosystem. We focus our science where it can matter most — advancing care in cancers with high unmet need, grounded in a deep understanding of disease biology and deliberate scientific choices that connect discovery to meaningful impact in the real world.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - [email protected]
Equal opportunity, accessibility and legal noticesGSK's statements, word for word
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Job intelligence
The context around this role
Live data · November 8, 2026
Salary intelligence
How the pay compares
This role's midpoint is 26% above the US median for Clinical Development roles at this level.
This roleEmployer provided
Director roles in Pennsylvania12 roles publishing pay
Director roles in the US215 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $284,250 | — | $473,750 |
| Pennsylvania (middle half) | $262,500 | $297,000 | $326,750 |
| All US (middle half) | $255,000 | $300,000 | $335,500 |
This role: GSK's own published range. Comparisons: the base pay employers published on open Clinical Development roles at the same level on Regulatory Jobs, November 8, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Development
The general path across 279 open Clinical Development roles on Regulatory Jobs, with the titles they carry most. Not GSK's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 38 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Collaboration and leadership18
- Clinical trial conduct17
- Documentation and SOPs11
- Investigations and CAPA3
- Regulatory submissions3
- Lab testing and methods2
- GMP and compliance1
- Data and digital systems1
Regulatory intelligence
The rules, regulations and standards behind this role
The regulations, guidance and standards that govern Clinical Development work in pharmaceuticals, led by the three this posting names, each linked to the agency or standards body that publishes it.
- ICHICH E6(R3) good clinical practice(official source, opens in a new tab)The international standard for the design, conduct and reporting of clinical trialsNamed in the posting
- FDA21 CFR Part 312(official source, opens in a new tab)Investigational New Drug applications and sponsor duties in drug trialsNamed in the posting
- FDA21 CFR Part 314(official source, opens in a new tab)Applications for FDA approval to market a new drug (NDA and ANDA)Named in the posting
- FDA21 CFR Part 50(official source, opens in a new tab)Protection of human subjects: informed consent in FDA-regulated trials
- FDA21 CFR Part 56(official source, opens in a new tab)Institutional review boards for FDA-regulated clinical investigations
- ICHICH E8(R1)(official source, opens in a new tab)General considerations for clinical studies and quality by design in trials
- MHRAUK MHRA(official source, opens in a new tab)The UK regulator of medicines and medical devices, including UKCA marking
- EUEU Clinical Trials Regulation 536/2014(official source, opens in a new tab)How clinical trials of medicines are authorized and run in the EU, through CTIS
- HHS45 CFR Part 46 (Common Rule)(official source, opens in a new tab)The federal policy for the protection of human research subjects
- NIH42 CFR Part 11(official source, opens in a new tab)Clinical trial registration and results reporting on ClinicalTrials.gov
- FDAFDA Bioresearch Monitoring (BIMO)(official source, opens in a new tab)FDA inspections of clinical investigators, sponsors, IRBs and GLP labs
- FDA21 CFR Part 11(official source, opens in a new tab)FDA rules for electronic records and electronic signatures
- HHSHIPAA Privacy Rule(official source, opens in a new tab)Federal protections for individually identifiable health information
- EUGDPR (Regulation 2016/679)(official source, opens in a new tab)The EU General Data Protection Regulation for personal data, including health data
- ICHICH E9 and E9(R1)(official source, opens in a new tab)Statistical principles for clinical trials and estimands
- FDA21 CFR 314.80 and 600.80(official source, opens in a new tab)Postmarketing reporting of adverse drug and biologic experiences
Company hiring pulse
GSK on Regulatory Jobs
- 36
- Open roles
- 36
- Distinct roles
- 7
- Locations
By discipline
- Clinical19 53%
- Quality13 36%
- Regulatory4 11%
By level
- Director19 53%
- Associate & Specialist8 22%
- Manager4 11%
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Executive Medical Director, Early Clinical Development Lead - Oncology - Lung & Head/Neck Cancers at GSK
Applications close November 21. $284K–$474K a year, employer provided.