New · posted Oct 31
Nurix Therapeutics · Biotechnology
Director, Drug Safety
- Brisbane, CA
- On-site
- Full-time
- Director
The role
Join Nurix’s pharmacovigilance team to help ensure patient safety across our clinical pipeline of targeted protein degradation therapies. As Director, Drug Safety, you’ll lead aggregate safety analysis, benefit–risk assessments, and safety strategy for assigned programs — shaping how we evaluate risk and bring new medicines safely to patients. It’s a chance to influence critical safety decisions at the intersection of clinical medicine, data, and drug development.
Medical Safety Leadership
- Serve as the medical safety lead for assigned products, providing clinical and pharmacovigilance expertise to safety strategy and activities
- Lead aggregate safety data analysis for signal detection, signal evaluation, and risk characterization
- Conduct medical review and interpretation of safety data, contributing to benefit–risk assessments
- Monitor emerging safety signals and proactively address potential safety risks through appropriate internal and external communication
Regulatory and Safety Documentation
- Oversee medical review of Individual Case Safety Reports (ICSRs)
- Author and review regulatory safety documents, including Development Safety Update Reports (DSURs) and safety sections of INDs and regulatory briefing books
- Contribute to safety responses to regulatory authorities and participate in regulatory interactions
- Provide clinical leadership during inspections and audits related to safety and risk management
Clinical Development Support
- Provide clinical input into safety aspects of clinical trial protocols, informed consent forms, and investigator brochures
- Collaborate with clinical development, regulatory affairs, medical affairs, and other stakeholders to ensure a consistent global safety strategy
Governance and Cross-Functional Collaboration
- Serve on safety governance committees, supporting strategic decision-making for risk mitigation and benefit–risk evaluation
What you need
What You’ll Bring
- Advanced clinical or scientific degree, such as MD, DO, PharmD, or equivalent relevant training and experience
- Clinical experience preferred
- 5–10 years of experience in pharmacovigilance/drug safety within the pharmaceutical or biotechnology industry
- Experience supporting early clinical development and small biotechnology companies
- Demonstrated expertise in aggregate safety analysis and benefit–risk evaluation
- Strong knowledge of global pharmacovigilance regulations and guidance (ICH, FDA, EMA, MHRA)
- Experience interacting with global health authorities on safety matters
- Familiarity with signal detection and safety surveillance tools and databases
- Strong communication, collaboration, and cross-functional leadership skills
- Ability to interpret complex clinical and safety data and translate insights into regulatory and business strategy
- Ability to work effectively and collaboratively in a fast-paced, growing organization across functional boundaries
The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.
Pay
$247,300 – $317,100 a year
Employer providedSalary Range: Non-MD $247,300 - $280,400 | MD $295,000 - $317,100
Where you'll work
Brisbane, CAOn-siteOpen in Maps (opens in a new tab)
More jobs in Brisbane, CA
From the posting
About Nurix
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
About Nurix Therapeutics
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 9% above the US median for Clinical Safety & Pharmacovigilance roles at this level.
This roleEmployer provided
Director roles in California18 roles publishing pay
Director roles in the US69 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $247,300 | — | $317,100 |
| California (middle half) | $227,125 | $254,250 | $280,750 |
| All US (middle half) | $213,500 | $260,000 | $281,000 |
This role: Nurix Therapeutics's own published range. Comparisons: the base pay employers published on open Clinical Safety & Pharmacovigilance roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Safety & Pharmacovigilance
The general path across 113 open Clinical Safety & Pharmacovigilance roles on Regulatory Jobs, with the titles they carry most. Not Nurix's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 24 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Collaboration and leadership9
- Clinical trial conduct4
- Quality systems and risk3
- GMP and compliance2
- Documentation and SOPs2
- Investigations and CAPA1
- Regulatory submissions1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
Company hiring pulse
Nurix on Regulatory Jobs
- 15
- Open roles
- 15
- Distinct roles
- 1
- Locations
By discipline
- Regulatory5 33%
- Quality5 33%
- Clinical5 33%
By level
- Director8 53%
- Manager5 33%
- Senior & Principal2 13%
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Director, Drug Safety at Nurix
Open until filled. $247K–$317K a year, employer provided.