New · posted Oct 31
Alnylam Pharmaceuticals · Biotechnology
Director, Clinical Research- Benign Hematology
- Cambridge, MA
- On-site
- Full-time
- Director
The role
Alnylam Pharmaceuticals is seeking an imaginative physician drug developer, with the flexibility and confidence to work across diseases within the neurology and hematology therapeutic area. This role includes the opportunity to provide clinical leadership in developing RNAi therapeutics in Alnylam’s expanding portfolio, which spans from rare genetic to common diseases.
The successful candidate’s primary role will be one of the clinical study leads working on the plasminogen program transitioning from Phase 2 to Phase 3. The Director will report directly into the program clinical development strategy lead who provides the clinical research oversight of the program. The Director is expected to play a leading and influencing role in the overall clinical development strategies and drive progress and operational excellence of his/her clinical trial(s). This work will also involve extensive consultation and collaboration with external experts. The Director, Clinical Research, will work in a matrix organization across Regulatory, Biostatistics, Clinical Operations, Preclinical, Commercial & Quality Assurance teams to ensure fully harmonized and integrated development strategies. The Director will be a key Alnylam Development spokesperson at external meetings, including regulatory interactions and scientific meetings.
The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).
What you need
A highly driven, dynamic, engaged and accomplished physician-scientist with experience and insight will thrive in this role. Specific qualifications include:
- MD with strong research background or MD PhD with best of class clinical and/or research training as shown through research support and peer-reviewed publications.
- Board Certification (or equivalent) or specialist training in neurology is desirable
- 3+ years industry experience or equivalent clinical academic research experience
- Sound scientific and clinical judgment
- Familiarity with concepts of clinical research and clinical trials, including biostatistics, and regulatory agency organization, guidelines, and practices
- Ability to effectively present ideas and document complex medical/clinical concepts in both written and oral communication
- History of critical thinking and problem solving while exhibiting superior judgment and a balanced, realistic understanding of issues
- Outstanding leadership and collaboration skills working within a matrix environment
- Thrives in highly entrepreneurial biotech environment and embraces Alnylam’s culture of science, passion and urgency.
What you'll do
- Be a subject matter expert for the relevant disease area(s)
- Be the strategic leader providing a strong, clear voice for the clinical program
- Develop creative but realistic approaches to drug development and lead clinical efforts towards global regulatory approvals
- Oversight of trial conduct and safety
- Collaborate closely with Preclinical, Regulatory Affairs and Medical Affairs to ensure tight strategic integration of product development plans.
- Be accountable via Clinical Research and Operations for all relevant timelines and deliverables.
- Supervise closely all major written deliverables (regulatory submissions, original articles, abstracts), and presentation materials.
- Be responsible for final review and sign off with respect to all controlled documents including protocols, investigator brochures, and informed consent forms.
- Influence internal and external audiences in a high impact, highly visible fashion
Pay and benefits
$255,000 – $345,000 a year
Employer providedMedical, dental, and vision coverage
Life and disability insurance
401(k) with company match
Paid time off and holidays
Annual bonus and equity eligibility
Family resources and leave
Where you'll work
Cambridge, MAOn-siteOpen in Maps (opens in a new tab)
More jobs in Cambridge, MA
From the posting
About Alnylam
We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers
U.S. Pay Range
$255,000—$345,000 USD
Equal opportunity, accessibility and legal noticesAlnylam Pharmaceuticals's statements, word for word
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.
Before applying, please review Alnylam's Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 1% above the US median for Clinical Development roles at this level.
This roleEmployer provided
Director roles in Massachusetts40 roles publishing pay
Director roles in the US93 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $255,000 | — | $345,000 |
| Massachusetts (middle half) | $255,000 | $298,000 | $308,250 |
| All US (middle half) | $258,000 | $298,000 | $318,500 |
This role: Alnylam Pharmaceuticals's own published range. Comparisons: the base pay employers published on open Clinical Development roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Development
The general path across 116 open Clinical Development roles on Regulatory Jobs, with the titles they carry most. Not Alnylam's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 22 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Collaboration and leadership9
- Clinical trial conduct4
- Documentation and SOPs3
- Regulatory submissions2
- Investigations and CAPA1
Company hiring pulse
Alnylam on Regulatory Jobs
- 15
- Open roles
- 14
- Distinct roles
- 4
- Locations
By discipline
- Clinical8 53%
- Regulatory4 27%
- Quality3 20%
By level
- Director8 53%
- Manager3 20%
- Senior & Principal2 13%
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Director, Clinical Research- Benign Hematology at Alnylam
Open until filled. $255K–$345K a year, employer provided.