New · posted Oct 24
Eli Lilly · Pharmaceuticals
Sr. Principal Scientist, Quality Control
- Lebanon, IN
- On-site
- Full-time
- Senior & Principal
The role
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.
Lilly is currently constructing a cutting-edge facility for the manufacture of new modalities, including Gene Therapy. Located in Lebanon, Indiana, this facility (LP2) will be Lilly’s most technically advanced manufacturing site focused on the delivery of the next wave of innovative products at Lilly. It will include next-generation manufacturing technologies and advanced data collection and analysis platforms that will deliver improvements in safety and quality, and process performance. This is a unique opportunity to be a part of the team for the startup of a greenfield manufacturing site, and the successful candidate will help to design, commission, and start up the facility for both clinical and commercial supply. The Quality Control Laboratory assures patients worldwide receive safe and efficacious drug and drug/device combination products through effective execution of product testing.
The Sr. Principal Chemist is an individual contributor and site subject matter expert (SME) who supports new product introductions, commercialization, and ongoing commercial manufacturing/testing in the LP2 Quality Control laboratory for gene therapy and other advanced therapy products, including those from new acquisitions and internal development streams. This role executes assays, supports laboratory site readiness, and provides technical expertise during post-start operations. The Sr. Principal Scientist partners closely with the Site QC Lead and laboratory team members to ensure timely, compliant, and scientifically sound testing delivery.
What you need
Basic Qualifications
- Bachelor's degree in chemistry, biochemistry, molecular biology, or another related science discipline
- 7+ years of advanced therapy experience in one or more of the following: gene therapy, LVV, LNP, AAV).
Additional Skills/ Preferences
- Hands-on experience with analytical testing in these spaces in a commercialization and routine commercial manufacturing environment.
- Previous experience in/ with analytical methods for viral vector (AVV, LVV) and non-viral vector (LNP, etc) products, e.g., ddPCR/qPCR, ELISA, capsid characterization, and cell-based potency assays.
- Previous experience in/ with analytical method transfer, qualification, and validation.
- Previous experience in/ with new product introduction or technology transfer, including products from acquired or external programs.
- Previous experience in/ with laboratory or facility start-up.
- Proficient in Root Cause Analysis methodology and laboratory investigation of deviations and out-of-specification results.
- Proven ability to serve as a technical SME and influence cross-functional teams without direct authority.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$66,000 - $171,600
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
Skills named in this posting
What you'll do
- Serve as a site SME for gene therapy analytical methods, supporting the Site QC Lead and laboratory team members with technical guidance, troubleshooting, and investigation support.
- Support new product introductions and commercialization in the QC laboratory, including method transfer, qualification, and validation for products originating from new acquisitions and internal development streams.
- Execute assays hands-on in support of in-process, release, and stability testing, including routine and non-routine testing, ensuring data integrity and compliance with GMP requirements.
- Support laboratory site readiness activities, including equipment and method readiness, procedure development, and testing capability build-out, and provide technical support for post-start operations and lifecycle management of methods.
- Partner with Technical Services/Manufacturing Science, Analytical Development, Quality Assurance, and external partners to ensure technical alignment and testing readiness for new and existing products.
- Author and review technical documents, including protocols, reports, procedures, and investigations, and support inspection readiness and regulatory inspections as a technical SME, while training and mentoring laboratory team members.
Pay and benefits
$66,000 – $171,600 a year
Employer providedCompany bonus
401(k)
Pension
Medical, dental, vision and prescription drug benefits
Flexible spending accounts
Life insurance and well-being benefits
Where you'll work
Lebanon, INOn-siteOpen in Maps (opens in a new tab)
More jobs in Lebanon, INJob intelligence
The context around this role
Live data · October 25, 2026
Salary intelligence
How the pay compares
This role's midpoint is 24% above the US median for Quality Control roles at this level.
This roleEmployer provided
Senior & Principal roles in Indiana10 roles publishing pay
Senior & Principal roles in the US57 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $66,000 | — | $171,600 |
| Indiana (middle half) | $78,500 | $78,500 | $89,750 |
| All US (middle half) | $78,500 | $95,500 | $115,000 |
This role: Eli Lilly's own published range. Comparisons: the base pay employers published on open Quality Control roles at the same level on Regulatory Jobs, October 25, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Quality Control
The general path across 323 open Quality Control roles on Regulatory Jobs, with the titles they carry most. Not Lilly's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 24 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Lab testing and methods13
- Collaboration and leadership6
- Investigations and CAPA3
- GMP and compliance2
- Validation and qualification2
- Documentation and SOPs1
- Data and digital systems1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
- FDA21 CFR Parts 210 and 211(official source, opens in a new tab)FDA current good manufacturing practice for finished pharmaceuticals
- FDAFDA data integrity guidance(official source, opens in a new tab)Data Integrity and Compliance With Drug CGMP: Questions and Answers
- FDAFDA OOS guidance(official source, opens in a new tab)Investigating Out-of-Specification (OOS) Test Results for Pharmaceutical Production
- ICHICH quality guidelines(official source, opens in a new tab)Q1 stability, Q2(R2) analytical validation, Q7, Q9 risk management, Q10 quality systems
Company hiring pulse
Lilly on Regulatory Jobs
- 52
- Open roles
- 52
- Distinct roles
- 10
- Locations
By discipline
- Quality40 77%
- Regulatory11 21%
- Compliance & Safety1 2%
By level
- Director20 38%
- Senior & Principal20 38%
- Associate & Specialist8 15%
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Sr. Principal Scientist, Quality Control at Lilly
Open until filled. $66K–$172K a year, employer provided.