New · posted Oct 31
Centessa Pharmaceuticals · Pharmaceuticals
Senior Clinical Trial Manager (Contract)
- Remote, US
- Remote
- Contract
- Manager
The role
Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions.
Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026.
Description of Role
Centessa is seeking a (contract-to-hire) Senior Clinical Trial Manager (Sr. CTM) to lead the execution of global clinical studies from startup through closeout and clinical study report. This role is a temporary position with the potential to convert to a permanent role, accountable for study delivery, including operational strategy, timelines, budget, quality, vendor oversight, risk management, and inspection readiness. This individual in this role will lead cross-functional teams and manage CROs and external vendors to ensure studies are conducted efficiently, compliantly, and in alignment with program objectives.
What you need
- Bachelor's degree in a scientific, health-related, or equivalent discipline required.
- 8+ years of clinical research experience, including 5+ years of clinical trial management experience within a sponsor or CRO environment. 2+ years of managing Phase 1 Healthy Volunteer studies.
- Experience in standard clinical pharmacology package studies such as: First in Human, Drug to Drug Interaction, Human Absorption, Metabolism, Excretion and Mass Balance, Relative Bioavailability, Bioequivalence, Organ Impairment, Abuse Liability studies.
- Demonstrated experience independently leading Phase 1 studies, global Phase II and/or Phase III clinical trials.
- Experience managing CROs, CRUs, central vendors, and cross-functional study teams.
- Neuroscience/CNS clinical development experience preferred.
- Experience supporting inspection readiness, audits, and regulatory interactions preferred.
What you'll do
- Lead the planning, execution, and oversight of global clinical trials from startup through closeout.
- Serve as the primary operational lead for assigned studies, driving cross-functional alignment and execution.
- Develop and manage study timelines, budgets, enrollment forecasts, risk mitigation plans, and key performance metrics.
- Oversee CROs and external vendors to ensure delivery against scope, quality standards, timelines, and budget.
- Drive critical study milestones, including site activation, enrollment, database lock, and study closeout.
- Review and approve study plans, vendor deliverables, and trial documentation to ensure compliance with protocol, GCP, and regulatory requirements.
- Identify operational risks and issues, implement mitigation strategies, and escalate as appropriate.
- Lead study team meetings and provide regular updates to stakeholders and senior management.
- Ensure Trial Master File (TMF) quality, completeness, and inspection readiness throughout the study lifecycle.
- Support regulatory submissions, audits, inspections, and Health Authority interactions.
- Contribute to process improvements and mentor junior clinical operations team members as needed.
- Collaborate effectively with global teams, investigators, CROs, and vendors across multiple regions.
Pay and benefits
$145,600 – $208,000 a year
Employer provided$70.00 – $100.00 an hour · yearly at 2,080 hours (40 a week)
How this comparesThe hourly range for this position is $70.00 to $100.00 per hour. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.
Contractors engaged through Centessa are employed through a third-party agency that serves as the employer of record and provides access to a comprehensive benefits package. Eligible contractors may enroll in medical plans, including PPO and EPO options, as well as dental and vision coverage after 30 days. Additional perks, such as a 401(k), wellness programs, and other discounts, may also be available to eligible contractors.
Medical plans (PPO and EPO)
Dental coverage
Vision coverage
401(k)
Wellness programs
From the posting
About Centessa Pharmaceuticals
Work Location
The Senior Clinical Trial Manager role is a based in the US (Remote), with occasional travel required.
POSITION: Temporary, non-exempt
Equal opportunity, accessibility and legal noticesCentessa Pharmaceuticals's statements, word for word
EEOC Statement: Centessa Pharmaceuticals, a wholly owned subdisary of Eli Lilly and Company believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. We will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 9% above the US median for Clinical Trial Management roles at this level.
This roleEmployer provided
Manager roles in Massachusetts6 roles publishing pay
Manager roles in the US26 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $145,600 | — | $208,000 |
| Massachusetts (middle half) | $155,500 | $175,000 | $176,500 |
| All US (middle half) | $150,000 | $162,000 | $175,000 |
This role: Centessa Pharmaceuticals's own published range, converted to a year at 2,080 hours. Comparisons: the base pay employers published on open Clinical Trial Management roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Trial Management
The general path across 33 open Clinical Trial Management roles on Regulatory Jobs, with the titles they carry most. Not Centessa Pharmaceuticals's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 22 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Clinical trial conduct11
- Collaboration and leadership8
- GMP and compliance5
- Documentation and SOPs2
- Investigations and CAPA2
- Quality systems and risk2
- Regulatory submissions1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
Company hiring pulse
Centessa Pharmaceuticals on Regulatory Jobs
- 5
- Open roles
- 5
- Distinct roles
- 2
- Locations
By discipline
- Clinical3 60%
- Regulatory1 20%
- Quality1 20%
By level
- Manager3 60%
- Director1 20%
- Senior & Principal1 20%
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Senior Clinical Trial Manager (Contract) at Centessa Pharmaceuticals
Open until filled. $146K–$208K a year, employer provided.