New · posted Nov 1
ICON · Biotechnology
Senior Clinical Research Associate
- Los Angeles, CA
- Hybrid
- Full-time
- Senior & Principal
The role
Senior Clinical Research Associate - Oncology - Los Angeles, CA
At ICON Strategic Solutions, you will work in a sponsor-dedicated model, supported by ICON’s global expertise.
As the world’s largest FSP organisation, with over 90 sponsor partnerships, we offer stability, career development and a collaborative environment where your work contributes to the development of treatments that benefit patients worldwide.
The Sr. Clinical Research Associate (Sr. CRA) will be responsible for performing investigative site management and monitoring activities throughout the clinical trial lifecycle. This Sr. CRA role will support the client's Oncology clinical trials to ensure data integrity, subject safety, and inspection readiness at the clinical investigative sites.
What you need
Bachelor’s degree (scientific field preferred)
5+ years monitoring clinical trials independently conducting on-site and remote monitoring visits. Atleast 2 years monitoring solid tumor clinical trials.
1+ years early development trial experience
Solid tumor clinical trial experience is required
Experience utilizing Veeva systems is highly preferred
Demonstrated experience developing/maintaining site relationships and securing compliance
Expertise in GxPs and Oncology monitoring techniques (including Risk-Based Monitoring) and terminology
Experience collaborating with sites from initial engagement through close-out phases
Experience activating sites
Experience training site staff
Experience supporting sites and/or sponsors in regulatory inspections
Experience working within a Functional Services (or in-house) monitoring model is preferred
Willing to travel up to 50%
Employment with ICON is contingent upon having the legal right to work in the country where the role is based.
What you'll do
Perform site management activities to support the client's Oncology site success and maintain a continuous state of inspection readiness
Act as the primary contact and facilitate efficient communications between the the client's clinical trial team and the sites
Perform remote and on-site monitoring/co-monitoring visits (Site Qualification Visits, Site Initiation Visits, Interim Monitoring Visits and Close-Out Visits) to ensure data integrity and subject safety in the client's trials
May perform oversight activities to assess monitoring quality and train/mentor less experienced CRAs
Promptly document monitoring activities and submit/approve visit reports
Manage site essential document collection and TMF reconciliation with site files
Support sites with local Institutional Review Board (IRB)/Ethics Committee (EC) submissions and confirm approvals
Regularly review site Key Risk Indicator (KRI) metrics, issues and action items to detect trends and ensure prompt resolution
Independently determine root causes and develop/implement site Corrective Action and Preventive Action (CAPA) plans
Deliver training to ensure sites comply with the protocol, Standard Operating Procedures (SOPs), Good Clinical Practices (GCPs) and regulations
Support sites and the client's regulatory inspections
Contribute to site identification; drive site feasibility and qualification progress; and support site activation activities
Lead site engagement initiatives and foster relationships with key Oncology sites and networks
Pay and benefits
$110,520 – $138,150 a year
Employer provided$110,520.00-$138,150.00
Are you a current ICON Employee? Please click here to apply
Rewards & Benefits
Competitive base salary and performance related incentives
Health and wellbeing programmes including medical, dental, and vision coverage where applicable
Retirement and pension plans
Life assurance and disability coverage
Employee assistance programmes and wellbeing resources
Learning and development opportunities through structured training and career pathways
ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.
Benefits may include:
Benefits may vary depending on role and location.
Visit our careers site to read more about the benefits ICON offers.
Where you'll work
Los Angeles, CAHybridOpen in Maps (opens in a new tab)
More jobs in Los Angeles, CAEqual opportunity, accessibility and legal noticesICON's statements, word for word
Inclusion and Accessibility
ICON is an equal opportunity employer. We are committed to building an inclusive and accessible workplace where everyone feels valued and supported.
If you require reasonable accommodations during the recruitment process, please let us know or submit a request here.
Job intelligence
The context around this role
Live data · November 1, 2026
Salary intelligence
How the pay compares
This role's midpoint is level with the US median for Clinical Research roles at this level.
This roleEmployer provided
Senior & Principal roles in California14 roles publishing pay
Senior & Principal roles in the US50 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $110,520 | — | $138,150 |
| California (middle half) | $112,500 | $124,500 | $132,250 |
| All US (middle half) | $123,750 | $124,500 | $130,500 |
This role: ICON's own published range. Comparisons: the base pay employers published on open Clinical Research roles at the same level on Regulatory Jobs, November 1, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Clinical Research
The general path across 193 open Clinical Research roles on Regulatory Jobs, with the titles they carry most. Not ICON's own promotion track.
Career resources on Clinical Research
Skills DNA
What this role leans on
How many of the posting's 31 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Clinical trial conduct10
- Collaboration and leadership7
- GMP and compliance6
- Documentation and SOPs3
- Data and digital systems3
- Investigations and CAPA2
- Validation and qualification2
- Lab testing and methods1
- Regulatory submissions1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
Company hiring pulse
ICON on Regulatory Jobs
- 106
- Open roles
- 56
- Distinct roles
- 30
- Locations
By discipline
- Clinical96 91%
- Quality7 7%
- Regulatory3 3%
By level
- Senior & Principal45 42%
- Associate & Specialist43 41%
- Manager15 14%
More roles at ICON
- View role
Clinical Research Associate
San Antonio, TXAssociate & SpecialistPharmaceuticalsSalary not listed
- View role
West Coast Clinical Research Associate II
Remote, USSenior & PrincipalPharmaceuticalsSalary not listed
- View role
Clinical Trial Liaison
Orlando, FLSenior & PrincipalPharmaceuticalsSalary not listed
- View role
Senior CRA - Phase 1 Oncology Mountain West
Remote, USSenior & PrincipalPharmaceuticalsSalary not listed
Similar Clinical Research roles elsewhere
- View role
Clinical Research Associate/Senior Clinical Research Associate- FSP
ParexelRemote, US NortheastSenior & PrincipalBiotechnologySalary not listed
- View role
Sr. CRA, Oncology, IQVIA Biotech
IQVIADurham, NCSenior & PrincipalBiotechnology$105K–$198K
- View role
Senior Clinical Research Associate - Oncology
BeOne MedicinesRemote, USSenior & PrincipalBiotechnology$106K–$141K
Senior Clinical Research Associate at ICON
Open until filled. $111K–$138K a year, employer provided.