New · posted Oct 29
Revolution Medicines · Biotechnology
Director, CMC Regulatory
- Remote, US
- Remote
- Full-time
- Director
The role
The Director, CMC Regulatory (post-approval) is responsible for providing strategic, hands-on and operational leadership for global post-approval submissions and CMC activities for Rasonque and other commercial products in RevMed’s portfolio. This role will lead complex global CMC lifecycle regulatory strategies across products and manufacturing sites, enabling timely execution of post-approval regulatory activities while improving submission efficiency, and simplifying regulatory processes. The individual will also support the successful transition of commercial-stage programs to the CMC-RA post-approval function. When required, the individual will also support development programs working with CMC-RA colleagues to accomplish the required regulatory deliverables and submissions.
This is accomplished with a strong working knowledge of global regulations, guidelines, and regulatory precedence, coupled with a strong technical knowledge of development, technology transfers and manufacturing processes.
Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.
Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.
What you need
Required Skills, Experience and Education
Bachelor’s degree in Pharmaceutical Science, Chemistry, Chemical Engineering, or closely related scientific discipline.
Minimum of 15 years of experience in pharmaceutical/biotech drug development, including at least 5 years of hands-on global CMC regulatory affairs experience supporting post-approval lifecycle management of small molecule products, particularly solid oral dosage forms.
Strong knowledge of US and international regulations, current industry practices, with a demonstrated ability to interpret and apply requirements for commercial products.
Strong project and team leadership capabilities, with the ability to prioritize effectively, manage multiple complex programs, and foster cross-functional collaboration.
Effective written and verbal communication skills and interpersonal skills.
A collaborative, high-energy team player who thrives in a fast-paced, dynamic environment and embraces innovation and continuous improvement.
Preferred Skillsnice to have
Advanced degree (MS or Ph.D) in Pharmaceutical Science, Chemistry, Chemical Engineering, or closely related field.
Experience with other modalities regulated by CDER, e.g., antibody therapeutics, ADCs, etc.
The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.
Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Base Pay Salary Range
$201,000—$251,000 USD
What you'll do
Serve as regulatory lead on assigned commercial programs/projects.
Develop and implement post-approval regulatory strategies for assigned products defining filing approaches and data expectations for site changes, analytical updates, specification changes, site additions, and related lifecycle activities.
Provide high-quality, timely, and decisive regulatory advice to allow project teams to make well-informed decisions on product lifecycle planning; anticipate and resolve technical or operational issues that could impact submission timelines.
Lead preparation, review, and execution of supplements, variations, annual reports, renewals, and related submissions.
Perform regulatory assessments for change controls and deviations for assigned products by applying risk-based principles to categorize and prioritize post-approval changes.
Collaborate with cross-functional stakeholders and peers within PDM, RA, Quality, Commercial, and other functions including local in-country colleagues, to define and execute endorsed global regulatory strategies and accomplish high-quality, and timely post-approval submissions.
Monitor emerging regulatory guidance related to lifecycle management and apply it strategically to current and future submissions; identify opportunities to simplify lifecycle processes or accelerate submissions.
Support development programs when required to accomplish CMC-RA deliverables and submissions.
Provide guidance and mentorship to junior CMC-RA colleagues and contribute to improving CMC regulatory processes and submission standards.
Pay and benefits
$201,000 – $251,000 a year
Employer providedCompetitive cash compensation
Equity awards
Strong benefits
Learning and development opportunities
Equal opportunity, accessibility and legal noticesRevolution Medicines's statements, word for word
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [email protected].
We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.
Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.
If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to [email protected] so we can share these impersonations with our IT team for tracking and awareness.
Job intelligence
The context around this role
Live data · October 31, 2026
Salary intelligence
How the pay compares
This role's midpoint is 9% above the US median for Regulatory CMC roles at this level.
This roleEmployer provided
Director roles in California10 roles publishing pay
Director roles in the US46 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $201,000 | — | $251,000 |
| California (middle half) | $201,875 | $214,250 | $235,625 |
| All US (middle half) | $192,625 | $208,000 | $230,000 |
This role: Revolution Medicines's own published range. Comparisons: the base pay employers published on open Regulatory CMC roles at the same level on Regulatory Jobs, October 31, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Regulatory CMC
The general path across 91 open Regulatory CMC roles on Regulatory Jobs, with the titles they carry most. Not Revolution Medicines's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 25 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Collaboration and leadership10
- Regulatory submissions7
- GMP and compliance2
- Quality systems and risk2
- Lab testing and methods1
- Documentation and SOPs1
- Investigations and CAPA1
Company hiring pulse
Revolution Medicines on Regulatory Jobs
- 40
- Open roles
- 32
- Distinct roles
- 3
- Locations
By discipline
- Clinical25 63%
- Regulatory7 18%
- Quality7 18%
By level
- Director28 70%
- Manager9 23%
- Senior & Principal3 8%
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Director, CMC Regulatory at Revolution Medicines
Open until filled. $201K–$251K a year, employer provided.