New · posted Oct 15
Nurix Therapeutics · Biotechnology
Senior Director, Quality Control
- Brisbane, CA
- On-site
- Full-time
- Director
Open until filled
The role
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Nurix Therapeutics is seeking an experienced Senior Director, Quality Control to join the Analytical Development and Quality Control group. This individual will establish and lead a QC operational function, establishing operations, systems, and a team to support programs from CMC development through commercial manufacturing.
The ideal candidate brings deep expertise in small molecule QC, strong regulatory acumen, and proven experience managing external CDMO and CTL relationships. This role will represent QC in health authority inspections and audits, and will work cross-functionally with Quality, Analytical Development, and Manufacturing to ensure product quality and patient safety across the portfolio.
What you need
- Advanced degree in Chemistry, Pharmaceutics, Chemical Engineering, or related discipline. BS/MS with 16+ years of relevant experience, or PhD with 14+ years of relevant experience
- 5+ years in a QC leadership or management role, with demonstrated ability to build and mentor teams
- Deep experience in small molecule pharmaceutical development, including method lifecycle management and oversight of validation, release, and stability operations
- Proven experience managing external manufacturing and testing operations at CDMOs and CTLs
- Expertise with analytical methods such as HPLC, GC, dissolution, and microbiological testing
- Direct experience leading through health authority inspections and internal audits and conducting audits of manufacturing and testing sites.
- Deep working knowledge of cGMP, ICH guidelines, and USP/EP/JP compendial standards
- Experience contributing to global regulatory filings and health authority correspondence (e.g., responses to information requests, post-approval changes)
- Strong interpersonal and cross-functional collaboration skills, with the ability to influence and build consensus across Quality, Supply Chain, Analytical Development, and Manufacturing functions
What you'll do
- Build and lead the QC function: Establish QC systems and infrastructure; recruit, manage, and mentor internal QC staff and contractors
- Set QC strategy across the product lifecycle: Define and execute QC strategy spanning CMC development through commercial programs, ensuring alignment with company milestones and submission timelines
- Oversee QC operations internally and externally: Direct method validation, release and stability testing, data review, deviations, investigations, change control, and CAPA internally and at CDMOs, and CTLs
- Identify and manage quality risk: Proactively identify, assess, and escalate risks related to patient safety, product quality, shelf life, supply continuity, or GMP compliance; drive risk mitigation strategies in partnership with Analytical Development, Quality, and Manufacturing functions
- Lead QC through audits and inspections: Serve as QC lead during health authority inspections and internal audits; collaborate with Quality to conduct audits of GMP manufacturing and testing sites, including CDMOs and CTLs
- Support regulatory submissions and health authority interactions: Contribute to global regulatory filings; collaborate on responses to health authority information requests, regulatory commitments, and post-approval changes
- Direct stability programs: Develop and execute stability strategy in collaboration with Analytical Development leads, ensuring alignment with ICH guidelines and regional regulatory requirements
- Manage reference materials and retains: Oversee qualification and inventory of reference standards; develop sampling plans and manage sample retain programs
- Drive continuous improvement: Identify and implement process improvements, data integrity enhancements, and quality system upgrades (e.g., eQMS) to support a scalable, inspection-ready QC organization
- Travel up to 15% to CDMO, CTL, and manufacturing sites and supplier and scientific conferences
Pay
$280,200 – $319,800 a year
Employer providedSalary Range: $280,200 - $319,800
Where you'll work
Brisbane, CAOn-siteOpen in Maps (opens in a new tab)
More jobs in Brisbane, CA
From the posting
About Nurix
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
Job intelligence
The context around this role
Live data · October 15, 2026
Salary intelligence
How the pay compares
This role's midpoint is 51% above the US median for Quality Control roles at this level.
This roleEmployer provided
Director roles in California7 roles publishing pay
Director roles in the US25 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $280,200 | — | $319,800 |
| California (middle half) | $188,500 | $219,500 | $247,250 |
| All US (middle half) | $186,000 | $198,500 | $240,000 |
This role: Nurix Therapeutics's own published range. Comparisons: the base pay employers published on open Quality Control roles at the same level on Regulatory Jobs, October 15, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Quality Control
The general path across 275 open Quality Control roles on Regulatory Jobs, with the titles they carry most. Not Nurix's own promotion track.
Skills DNA
What this role leans on
How many of the posting's 22 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Lab testing and methods12
- Collaboration and leadership9
- GMP and compliance6
- Regulatory submissions6
- Validation and qualification3
- Quality systems and risk3
- Documentation and SOPs2
- Investigations and CAPA1
- Data and digital systems1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
- FDA21 CFR Parts 210 and 211(official source, opens in a new tab)FDA current good manufacturing practice for finished pharmaceuticals
- FDAFDA data integrity guidance(official source, opens in a new tab)Data Integrity and Compliance With Drug CGMP: Questions and Answers
- ICHICH quality guidelines(official source, opens in a new tab)Q1 stability, Q2(R2) analytical validation, Q7, Q9 risk management, Q10 quality systems
- USPUSP compendial chapters(official source, opens in a new tab)Bioburden (USP <61>), endotoxin (USP <85>), TOC (USP <643>) and water testing
Company hiring pulse
Nurix on Regulatory Jobs
- 11
- Open roles
- 11
- Distinct roles
- 1
- Locations
By discipline
- Quality6 55%
- Regulatory5 45%
By level
- Director7 64%
- Manager3 27%
- Senior & Principal1 9%
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Senior Director, Quality Control at Nurix
Open until filled. $280K–$320K a year, employer provided.