New · posted Oct 15
Tango Therapeutics · Biotechnology
Quality Management System Lead
- Boston, MA
- On-site
- Full-time
- Senior & Principal
Open until filled
The role
Own and continuously improve the QMS framework to ensure processes, document control, training, and quality records support consistent compliance across functions and regions.
What you need
What You Bring
- Bachelor’s degree in Life Sciences, Quality, or related discipline (required)
- Quality-related certification preferred (e.g., ASQ, ISO Lead Auditor, Quality Systems)
- Training in electronic QMS platforms advantageous
- 8–12 years in Quality Assurance or Compliance
- Hands-on experience managing QMS in regulated GxP environments
- Experience supporting QMS-related inspections and audits
- QMS design, lifecycle management, and governance
- GxP training systems and compliance tracking
- Data integrity and document control standards
- Process‑oriented, structured, and detail focused
- Strong communication and training skills
- Ability to simplify complex processes and drive alignment
What you'll do
Your Role
- Define and maintain QMS structure: policies, SOPs, work instructions, templates, and governance
- Ensure harmonization across GxP domains (GMP/GLP/GCP) and alignment with applicable regulations/standards
- Oversee document lifecycle management (authoring standards, review/approval, periodic review, archival)
- Ensure change control processes exist and are followed (QMS changes and cross-functional change impacts)
- Oversee GxP training framework (curricula, assignment rules, effectiveness checks, compliance reporting)
- Partner with functional owners to define role-based training requirements
- Ensure QMS records are complete, traceable, audit-ready, and meet data integrity principles
- Establish metrics and trending for QMS health (cycle time, overdue items, training compliance)
- Lead QMS simplification/optimization, including CAPA prevention initiatives based on trending and learnings
- Prepare Quality Management Review packages: KPIs, risks, audit outcomes, CAPA effectiveness, and improvement plans
Pay
$151,200 – $226,800 a year
Employer provided$151,200—$226,800 USD
Where you'll work
Boston, MAOn-siteOpen in Maps (opens in a new tab)
More jobs in Boston, MAFrom the posting
About Tango Therapeutics
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Equal opportunity, accessibility and legal noticesTango Therapeutics's statements, word for word
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Job intelligence
The context around this role
Live data · October 15, 2026
Salary intelligence
How the pay compares
This role's midpoint is 54% above the US median for Quality Assurance roles at this level.
This roleEmployer provided
Senior & Principal roles in Massachusetts25 roles publishing pay
Senior & Principal roles in the US284 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $151,200 | — | $226,800 |
| Massachusetts (middle half) | $108,500 | $125,000 | $133,000 |
| All US (middle half) | $103,375 | $122,750 | $137,500 |
This role: Tango Therapeutics's own published range. Comparisons: the base pay employers published on open Quality Assurance roles at the same level on Regulatory Jobs, October 15, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Quality Assurance
The general path across 845 open Quality Assurance roles on Regulatory Jobs, with the titles they carry most. Not Tango Therapeutics's own promotion track.
Career resources on Quality Assurance
Skills DNA
What this role leans on
How many of the posting's 23 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- Quality systems and risk12
- GMP and compliance11
- Collaboration and leadership10
- Documentation and SOPs5
- Investigations and CAPA2
- Data and digital systems2
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
- FDA21 CFR Parts 210 and 211(official source, opens in a new tab)FDA current good manufacturing practice for finished pharmaceuticals
- FDAFDA data integrity guidance(official source, opens in a new tab)Data Integrity and Compliance With Drug CGMP: Questions and Answers
- FDA21 CFR Part 58 (GLP)(official source, opens in a new tab)Good laboratory practice for nonclinical laboratory studies
- ICHICH E6 good clinical practice(official source, opens in a new tab)The international standard for the conduct of clinical trials
From Regulatory News
Manufacturing and quality coverage for this professionCompany hiring pulse
Tango Therapeutics on Regulatory Jobs
- 3
- Open roles
- 3
- Distinct roles
- 1
- Locations
By discipline
- Quality3 100%
By level
- Director1 33%
- Manager1 33%
- Senior & Principal1 33%
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Quality Management System Lead at Tango Therapeutics
Open until filled. $151K–$227K a year, employer provided.