New · posted Oct 15
Tango Therapeutics · Biotechnology
Manager, GMP Quality
- Boston, MA
- On-site
- Full-time
- Manager
Open until filled
The role
This role will report to the Director of Quality and operate across departments, supporting regulated activities and studies. This new role will support CMC development and clinical disposition activities for Tango’s development programs. Tango works in a matrixed, outsourced model where compliance and inspection readiness are key to our programs as we advance through the development cycle.
The Manager, Quality Assurance, will provide GMP QA oversight for Tango’s CMC development programs and clinical supply activities. This role partners cross-functionally with Technical Operations, Regulatory, and external manufacturing partners to ensure compliance with global GMP requirements while supporting the advancement of investigational therapies through clinical development.
What you need
What You Bring
- Bachelor's Degree in Chemistry, Biology, Engineering or related field plus 5 years pharma manufacturing, packaging or laboratory experience
- At least 5 years of direct QA/compliance experience working in biotechnology, pharmaceutical, laboratory, CRO or CMO environment
- Strong knowledge of global GMP regulations (FDA, EMA, ICH) applicable to investigational drug development.
- Experience providing QA oversight of drug product development across the pharmaceutical lifecycle Thorough understanding of creation/ review/approval of GMP documents such as specifications, test methods, stability protocols, batch records, and investigations
- Ability to collaborate effectively in a matrixed, cross-functional, and global environment.
- Strong oral/written communication skills
- Capable of analyzing a wide variety of information and data to make management decisions regarding potential risks associated with product quality or regulatory compliance
- Able to establish professional relationships and rapport with internal and external peers and experience working collaboratively with teams in a complex, matrixed, and global environment.
- Strong attention to detail and commitment to maintaining high quality and compliance standards.
- Strong project management and organizational skills, with the ability to manage multiple concurrent priorities.
What you'll do
Your Role
- Review batch documentation and dispositions materials for use in clinical trials
- Lead & manage strategic GMP QA activities associated with Tango CMC development programs
- Ensure compliance with regulations related to manufacturing, testing, packaging & distribution of investigational drug products and active pharmaceutical ingredients. Identify compliance gaps and propose solutions
- Execute and lead implementation of phase-appropriate quality guidance, review, and approval processes for product development programs across Phases 1–3
- Oversee projects independently, identifying, evaluating, and resolving product quality concerns in compliance with GMP requirements
- Identify trends related to development compounds, operations, etc.
- Ensure timely review, approval, and archival of GMP documentation and quality records
- Participate in GMP audits of CMOs, contract laboratories, and other vendors, providing recommendations regarding vendor qualification and continued use
- Mentor and support internal teams on GMP documentation, quality practices, and regulatory compliance
- Additional duties and responsibilities as assigned
Pay
$116,000 – $174,000 a year
Employer provided$116,000—$174,000 USD
Where you'll work
Boston, MAOn-siteOpen in Maps (opens in a new tab)
More jobs in Boston, MAFrom the posting
About Tango Therapeutics
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Equal opportunity, accessibility and legal noticesTango Therapeutics's statements, word for word
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Job intelligence
The context around this role
Live data · October 15, 2026
Salary intelligence
How the pay compares
This role's midpoint is 5% below the US median for Quality Assurance roles at this level.
This roleEmployer provided
Manager roles in Massachusetts18 roles publishing pay
Manager roles in the US105 roles publishing pay
| Annual base pay | Low | Median | High |
|---|---|---|---|
| This role | $116,000 | — | $174,000 |
| Massachusetts (middle half) | $116,500 | $133,250 | $153,000 |
| All US (middle half) | $126,000 | $153,000 | $167,500 |
This role: Tango Therapeutics's own published range. Comparisons: the base pay employers published on open Quality Assurance roles at the same level on Regulatory Jobs, October 15, 2026. Nothing is estimated.
Career trajectory
Where this role sits in Quality Assurance
The general path across 845 open Quality Assurance roles on Regulatory Jobs, with the titles they carry most. Not Tango Therapeutics's own promotion track.
Career resources on Quality Assurance
Skills DNA
What this role leans on
How many of the posting's 22 duty, requirement and summary lines touch each area. The posting's emphasis, not a proficiency score.
- GMP and compliance13
- Collaboration and leadership7
- Lab testing and methods5
- Documentation and SOPs5
- Investigations and CAPA4
- Validation and qualification1
Regulatory intelligence
The rules behind this role
Frameworks and standards this posting's work falls under, matched from its own words, each linked to the official source.
Company hiring pulse
Tango Therapeutics on Regulatory Jobs
- 3
- Open roles
- 3
- Distinct roles
- 1
- Locations
By discipline
- Quality3 100%
By level
- Director1 33%
- Manager1 33%
- Senior & Principal1 33%
More roles at Tango Therapeutics
- View role
Director/Senior Director, GCP Quality Assurance
Boston, MA · HybridDirectorBiotechnology$171K
- View role
Quality Management System Lead
Boston, MASenior & PrincipalBiotechnology$151K
Similar Quality Assurance roles elsewhere
- View role
Senior Manager, QA Compliance
Sarepta TherapeuticsAndover, MA +1 more · HybridManagerBiotechnology$136K–$170K
- View role
Senior Manager, Corporate Quality – R&D Audits
Sarepta TherapeuticsBedford, MA · HybridManagerBiotechnology$136K–$170K
- View role
Senior Manager, Quality
RepligenMarlborough, MAManagerBiotechnology$135K–$190K
- View role
Senior Manager, Quality Assurance Vendor & Audit Management
Genetix BiotherapeuticsSomerville, MA · HybridManagerBiotechnology$160K
Manager, GMP Quality at Tango Therapeutics
Open until filled. $116K–$174K a year, employer provided.